SIRS patients meeting definitions of acute kidney injury using peak serum creatinine in the 14 days following surgery
| All patients (n=6598)* | Patients with a preoperative eGFR ≥60 mL/min/1.73 m2 (n=4668) | Patients with a preoperative eGFR <60 mL/min/1.73 m2 (n=1930) | Statistical power to detect a 20% relative risk reduction (7000 patients) (%)† | |
|---|---|---|---|---|
| Primary definition | ||||
| AKI (a SIRS definition) | 2557 (38.8%) | 1678 (36.0%) | 879 (45.5%) | 99 |
| Alternate definitions | ||||
| AKI stage 2 or more (a SIRS definition) | 614 (9.3%) | 395 (8.5%) | 219 (11.3%) | 79 |
| AKI stage 3 or more (a SIRS definition) | 265 (4.0%) | 132 (2.8%) | 133 (6.9%) | 44 |
| Receipt of acute dialysis within 30 days | 164 (2.5%) | 71 (1.5%) | 93 (4.8%) | 29 |
| AKI (a SIRS definition) or death | 2625 (39.8%) | 1721 (36.9%) | 904 (46.8%) | 99 |
*Number of SIRS patients with data as of November 2013. We expect over 7000 patients will meet the criteria for the primary AKI analysis.
†Two-tailed α 0.05, χ2 test, assumes that the incidence observed in all patients (n=6598) will be the incidence observed in the placebo group.
AKI, acute kidney injury; eGFR, estimated-glomerular filtration rate; SIRS, Steroids In caRdiac Surgery trial.