n | Prevalences (cases/1000 births) | Crude change/year | Age adjusted change/year | |||||
---|---|---|---|---|---|---|---|---|
1999–2008 | 1999–2001 | 2006–2008 | Per cent (95% CI) | p Value | Per cent (95% CI) | p Value | ||
Total diagnosed anomalies | ||||||||
Chromosomal | ||||||||
All | 991 | 5.18 (4.87 to 5.52) | 4.95 (4.37 to 5.60) | 5.36 (4.81 to 5.97) | 1.01 (0.99 to 1.04) | 0.174 | 1.00 (0.98 to 1.02) | 0.878 |
DS | 548 | 2.87 (2.63 to 3.12) | 2.76 (2.34 to 3.26) | 3.10 (2.68 to 3.57) | 1.03 (1.00 to 1.06) | 0.079 | 1.01 (0.98 to 1.04) | 0.669 |
DS adjusted fetal loss | 435 | 2.27 (2.07 to 2.50) | 2.24 (1.86 to 2.70) | 2.46 (2.09 to 2.88) | 1.02 (0.99 to 1.06) | 0.161 | 1.00 (0.97 to 1.04) | 0.843 |
Non-chromosomal | ||||||||
All | 3090 | 16.16 (15.61 to 16.74 | 13.75 (12.78 to 14.80) | 17.76 (16.75 to 18.84) | 1.04 (1.02 to 1.05) | <0.001 | 1.04 (1.03 to 1.05) | <0.001 |
Nervous system | 456 | 2.38 (2.17 to 2.62) | 1.99 (1.63 to 2.42) | 2.84 (2.44 to 3.30) | 1.05 (1.01 to 1.08) | 0.007 | 1.05 (1.01 to 1.08) | 0.007 |
Urinary | 670 | 3.50 (3.25 to 3.78) | 2.41 (2.02 to 2.89) | 3.64 (3.19 to 4.16) | 1.04 (1.02 to 1.07) | 0.002 | 1.04 (1.01 to 1.07) | 0.003 |
Digestive | 304 | 1.59 (1.42 to 1.78) | 1.31 (1.03 to 1.68) | 1.83 (1.52 to 2.21) | 1.03 (0.99 to 1.08) | 0.101 | 1.03 (0.99 to 1.08) | 0.105 |
Limbs | 460 | 2.41 (2.19 to 2.64) | 1.62 (1.30 to 2.02) | 4.09 (3.61 to 4.63) | 1.17 (1.13 to 1.21) | <0.001 | 1.17 (1.13 to 1.21) | <0.001 |
Heart | 962 | 5.03 (4.72 to 5.36) | 4.87 (4.29 to 5.51) | 4.81 (4.29 to 5.40) | 1.00 (0.98 to 1.02) | 0.876 | 1.01 (0.98 to 1.03) | 0.619 |
Anomalies at birth | ||||||||
Chromosomal | ||||||||
All | 238 | 1.25 (1.09 to 1.42) | 1.49 (1.18 to 1.87) | 1.16 (0.91 to 1.46) | 0.97 (0.93 to 1.01) | 0.160 | 0.96 (0.92 to 1.00) | 0.080 |
DS | 139 | 0.73 (0.61 to 0.86) | 1.02 (0.77 to 1.35) | 0.66 (0.48 to 0.90) | 0.95 (0.9 to 1.01) | 0.098 | 0.95 (0.89 to 1.01) | 0.076 |
Non-chromosomal | ||||||||
All | 2442 | 12.77 (12.29 to 13.29) | 10.72 (9.86 to 11.65) | 14.07 (13.17 to 15.03) | 1.04 (1.03 to 1.06) | <0.001 | 1.04 (1.03 to 1.06) | <0.001 |
Nervous system | 166 | 0.87 (0.74 to 1.01) | 0.64 (0.45 to 0.91) | 1.17 (0.92 to 1.48) | 1.10 (1.04 to 1.16) | 0.001 | 1.10 (1.04 to 1.16) | 0.001 |
Urinary | 564 | 2.95 (2.71 to 3.21) | 1.87 (1.53 to 2.30) | 3.11 (2.70 to 3.59) | 1.05 (1.02 to 1.09) | <0.001 | 1.05 (1.02 to 1.09) | <0.001 |
Digestive | 276 | 1.44 (1.28 to 1.63) | 1.20 (0.93 to 1.55) | 1.65 (1.36 to 2.01) | 1.03 (0.99 to 1.08) | 0.115 | 1.03 (0.99 to 1.08) | 0.127 |
Limbs | 360 | 1.88 (1.70 to 2.09) | 1.33 (1.04 to 1.70) | 3.23 (2.80 to 3.71) | 1.17 (1.13 to 1.22) | <0.001 | 1.17 (1.13 to 1.22) | <0.001 |
Heart | 873 | 4.57 (4.27 to 4.88) | 4.73 (4.17 to 5.37) | 4.08 (3.60 to 4.62) | 0.98 (0.96 to 1.01) | 0.176 | 0.99 (0.97 to 1.01) | 0.340 |
DS, Down's syndrome.