The absolute and percentage change in lipids in response to initial statin treatment compared with the coefficient of variation, in 4512 patients randomised to pravastatin
| Lipid | Change | Change (%) | Rank | Variation (coefficient of variation) (%) | Change/coefficient of variation (%) | Rank* |
|---|---|---|---|---|---|---|
| Total cholesterol (mmol/L) | 1.16 | 21 | 7 | 0.30 (10) | 2.13 (2.11, 2.19) | 3 |
| LDL cholesterol (mmol/L) | 1.09 | 28 | 2 | 0.25 (28) | 2.20 (2.16, 2.24 | 1 |
| HDL cholesterol (mmol/L) | −0.04 | −4 | 10 | 0.01 (11) | −0.35 (−0.38, −0.33) | 10 |
| Total to HDL cholesterol ratio | 1.40 | 23 | 5 | 1.46 (20) | 1.81 (1.78–1.84) | 7 |
| LDL to HDL cholesterol ratio | 1.29 | 30 | 1 | 0.73 (20) | 1.95 (1.92–1.99) | 5 |
| Non-HDL cholesterol (mmol/L)† | 1.18 | 25 | 4 | 0.29 (11) | 2.20 (2.14, 2.21) | 1 |
| Triglycerides (mmol/L) | 0.19 | 11 | 8 | 0.27 (29) | 0.37 (0.35, 0.40) | 9 |
| Apolipoprotein A1 (g/L) | −0.07 | 6 | 9 | 0.014 (9) | −0.62 (−0.66, −0.60) | 8 |
| Apolipoprotein B (g/L) | 0.29 | 22 | 6 | 0.02 (12) | 1.86 (1.83, 1.91) | 6 |
| Apolipoprotein B/A1 | 0.27 | 26 | 3 | 0.02 (13) | 2.01 (1.98, 2.04) | 4 |
*Rank is based on the absolute size of the change/coefficient of variation, irrespective of direction.
†Total minus HDL cholesterol.
HDL, high-density lipoprotein; LDL, low-density lipoprotein.