Incidence of bleeding outcomes overall and in relation to VKA use for the cohort of patients with AF eligible for linkage, n=16513
| Overall | Current exposure | Recent exposure | Past exposure | No use | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Event | Number of outcome events | PY | Incidence* (95% CI) | Number of outcome events | PY | Incidence* (95% CI) | Number of outcome events | PY | Incidence* (95% CI) | Number of outcome events | PY | Incidence* (95% CI) | Number of outcome events | PY | Incidence* (95% CI) |
| All bleed | 1023 | 30693 | 3.3 (3.1 to 3.5) | 426 | 11236 | 3.8 (3.4 to 4.2) | 101 | 2238 | 4.5 (3.7 to 5.5) | 97 | 3573 | 2.7 (2.2 to 3.3) | 399 | 13645 | 2.9 (2.6 to 3.2) |
| Intracranial bleed | 120 | 31854 | 0.4 (0.3 to 0.5) | 46 | 11654 | 0.4 (0.3 to 0.5) | 15 | 2353 | 0.6 (0.4 to 1.1) | 8 | 3811 | 0.2 (0.1 to 0.4) | 51 | 14036 | 0.4 (0.3 to 0.5) |
| Extracranial bleed | 903 | 30778 | 2.9 (2.7 to 3.1) | 380 | 11246 | 3.4 (3.0 to 3.7) | 86 | 2245 | 3.8 (3.1 to 4.7) | 89 | 3593 | 2.5 (2.0 to 3.0) | 348 | 13695 | 2.5 (2.3 to 2.8) |
| GI bleed | 334 | 31545 | 1.1 (0.9 to 1.2) | 104 | 11560 | 0.9 (0.7 to 1.1) | 35 | 2330 | 1.5 (1.0 to 2.1) | 38 | 3733 | 1.0 (0.7 to 1.4) | 157 | 13921 | 1.1 (1.0 to 1.3) |
| Fatal bleed | 74 | 30693 | 0.2 (0.2 to 0.3) | 33 | 11236 | 0.3 (0.2 to 0.4) | 10 | 2238 | 0.4 (0.2 to 0.8) | 7 | 3573 | 0.2 (0.1 to 0.4) | 24 | 13645 | 0.2 (0.1 to 0.3) |
| Intracranial bleed | 45 | 31854 | 0.1 (0.1 to 0.2) | 23 | 11654 | 0.2 (0.1 to 0.3) | 6 | 2353 | 0.3 (0.1 to 0.6) | 5 | 3811 | 0.1 (<0.1 to 0.3) | 11 | 14036 | 0.1 (<0.1 to 0.1) |
| Extracranial bleed | 29 | 30778 | 0.1 (0.1 to 0.1) | 10 | 11246 | 0.1 (<0.1 to 0.2) | 4 | 2245 | 0.2 (<0.1 to 0.5) | 2 | 3593 | 0.1 (<0.1 to 0.2) | 13 | 13695 | 0.1 (0.1 to 0.2) |
| GI bleed | 20 | 31545 | 0.1 (<0.1 to 0.1) | 4 | 11560 | 0.0 (<0.1 to 0.1) | 3 | 2330 | 0.1 (<0.1 to 0.4) | 2 | 3733 | 0.1 (<0.1 to 0.2) | 11 | 13921 | 0.1 (<0.1 to 0.1) |
| Non-fatal bleed | 949 | 30693 | 3.1 (2.9 to 3.3) | 393 | 11236 | 3.5 (3.2 to 3.9) | 91 | 2238 | 4.1 (3.3 to 5.0) | 90 | 3573 | 2.5 (2.0 to 3.1) | 375 | 13645 | 2.7 (2.5 to 3.0) |
| Intracranial bleed | 75 | 31854 | 0.2 (0.2 to 0.3) | 23 | 11654 | 0.2 (0.1 to 0.3) | 9 | 2353 | 0.4 (0.2 to 0.7) | 3 | 3811 | 0.1 (<0.1 to 0.2) | 40 | 14036 | 0.3 (0.2 to 0.4) |
| Extracranial bleed | 874 | 30778 | 2.8 (2.7 to 3.0) | 370 | 11246 | 3.3 (3.0 to 3.6) | 82 | 2245 | 3.7 (2.9 to 4.5) | 87 | 3593 | 2.4 (1.9 to 3.0) | 335 | 13695 | 2.4 (2.2 to 2.7) |
| GI bleed | 314 | 31545 | 1.0 (0.9 to 1.1) | 100 | 11560 | 0.9 (0.7 to 1.1) | 32 | 2330 | 1.4 (0.9 to 1.9) | 36 | 3733 | 1.0 (0.7 to 1.3) | 146 | 13921 | 1.0 (0.9 to 1.2) |
*Number of cases per 100 PY.
AF, atrial fibrillation; GI, gastrointestinal; PY, person-years; VKA, vitamin K antagonists.