Change in clinical variables between prerandomisation and 6-week postrandomisation*
| Prerandomisation | Postrandomisation | Change from baseline† | p Value‡ | ||||
|---|---|---|---|---|---|---|---|
| Control | Hydration | Control | Hydration | Control | Hydration | ||
| 24 h urine volume, L | 2.0 (0.7) | 2.3 (0.6) | 1.7 (0.6) | 3.0 (1.2) | −0.2 (0.4) | 0.7 (1.0) | 0.002 |
| 24 h urine creatinine, mmol/day | 10.9 (4.3) | 13.0 (4.0) | 10.2 (3.6) | 13.5 (4.7) | −0.8 (1.7) | 0.7 (2.3) | 0.08 |
| 24 h urine sodium, mmol/day | 155 (68) | 163 (68) | 114 (66) | 148 (55) | −41 (29) | −15 (41) | 0.10 |
| 24 h urine potassium, mmol/day | 58 (30) | 69 (32) | 56 (25) | 71 (34) | −2.0 (19) | 2.3 (15) | 0.53 |
| 24 h urine urea, mmol/day | 344 (136) | 388 (136) | 304 (116) | 407 (116) | −40 (66) | 19 (82) | 0.07 |
| 24 h urine osmolality, mOsm/kg | 430 (123) | 393 (161) | 410 (75) | 317 (110) | −19 (97) | −76 (149) | 0.27 |
| 24 h urine ACR, mg/mmol, median (IQR) | 20 (7, 77) | 16 (6, 60) | 17 (6, 86) | 16 (5, 78) | −0.6 (−8, 9.2) | 0.9 (−2.7, 21.5) | 0.69 |
| Serum sodium, mmol/L | 139 (2.7) | 138 (2.2) | 138 (3.4) | 138 (1.8) | −1.5 (2.9) | −0.5 (2.7) | 0.37 |
| Serum urea, mmol/L | 12 (3) | 12 (3) | 13 (3) | 12 (4) | 1.0 (2.6) | 0.6 (2.6) | 0.69 |
| Serum osmolality, mOsm/kg | 305 (10) | 302 (6) | 305 (10) | 302 (7.3) | 0.0 (3.7) | 0.06 (5.7) | 0.98 |
| eGFR, mL/min/1.73 m2 | 39 (11) | 42 (10) | 38 (12) | 41 (10) | −1.8 (5) | −0.8 (4.0) | 0.61 |
| Cystatin C, mg/L | 1.6 (0.5) | 1.6 (0.4) | 1.6 (0.5) | 1.6 (0.5) | 0.0 (0.2) | 0.0 (0.2) | 0.90 |
| Specific gravity (g) | 1.01 (0.01) | 1.01 (0.01) | 1.01 (0.01) | 1.01 (0.01) | −0.01 (0.01) | −0.01 (0.01) | 0.89 |
*Means and SDs are reported unless otherwise reported.
†Last follow-up—baseline.
‡Change from baseline compared between groups using the independent t test.
ACR, albumin to creatinine ratio; eGFR, estimated glomerular filtration rate.