Antibacterial activity, bacterial sensitivity, intermediate sensitivity and resistance to antibiotics commonly used against ESBL-negative and ESBL-positive Escherichia coli
| Antimicrobial drug | ESBL-negative E coli (41 isolates) | ESBL-positive E coli (46 isolates) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MIC50 | MIC90 | S% | I% | R% | MIC50 | MIC90 | S% | I% | R% | |
| Fosfomycin tromethamine* | 0.125 | 05 | 95.1 | 4.9 | 0.0 | 0.125 | 128 | 87.0 | 8.7 | 4.3 |
| Levofloxacin | 1 | 16 | 61.0 | 4.9 | 34.1 | 8 | 32 | 21.7 | 15.3 | 63.0 |
| Moxifloxacin | 0.5 | 32 | – | – | – | 16 | 64 | – | – | – |
| Cefdinir | 0.25 | 2 | 87.8 | 2.4 | 9.8 | 256 | >256 | 4.3 | 2.2 | 93.5 |
| Cefixime | 0.5 | 2 | 82.9 | 9.8 | 7.3 | 32 | 128 | 4.3 | 6.6 | 89.1 |
| Cefaclor | 2 | 4 | 90.2 | 2.5 | 7.3 | >256 | >256 | 2.2 | 2.1 | 95.7 |
| Cefprozil | 2 | 8 | 90.2 | 0.0 | 9.8 | >256 | >256 | 2.2 | 2.1 | 95.7 |
| Cefuroxime | 4 | 16 | 82.9 | 7.3 | 9.8 | >256 | >256 | 0.0 | 0.0 | 100.0 |
| Amoxicillin/clavulanic acid | 4 | 16 | 87.8 | 4.9 | 7.3 | 8 | 16 | 63.0 | 34.8 | 2.2 |
| Cefotaxime | 0.062 | 0.5 | 95.1 | 0.0 | 4.9 | 64 | 256 | 2.2 | 0.0 | 97.8 |
| Nitrofurantoin | 16 | 32 | 90.2 | 4.9 | 4.9 | 16 | 32 | 93.5 | 6.5 | 0.0 |
*Determination of the breakpoint of fosfomycin tromethamine to Enterobacteriaceae (sensitivity rate ≤64 mg/L; resistance rate ≥256 mg/L).
E coli, Escherichia coli; ESBL, extended spectrum β-lactamases; I, intermediate; MIC, minimal inhibitory concentration; R, resistant; S, susceptible.