Table 1

Diagnostic criteria for tuberous sclerosis complex

Major featuresMinor features

  1. Facial angiofibromas or forehead plaque

  2. Non-traumatic ungula or periungual fibroma

  3. Hypomelanotic macules (three or more)

  4. Shagreen patch (connective tissue nevus)

  5. Multiple retinal nodular hamartomas

  6. Cortical tuber

  7. Subependymal nodule

  8. Subependymal giant cell astrocytoma

  9. Cardiac rhabdomyoma, single or multiple

  10. Lymphangioleiomyomatosis

  11. Renal angiomyolipoma

  1. Multiple, randomly distributed pits in dental enamel

  2. Hamartomatous rectal polyps

  3. Bone cysts

  4. Cerebral white matter radial migration lines

  5. Gingival fibromas

  6. Non-renal hamartoma

  7. Retinal achromic patch

  8. ‘Confetti’ skin lesions

  9. Multiple renal cystsc