Vitamin D status and mortality and HIV disease progression in patients with HIV infection and tuberculosis
| Univariate | Multivariate | ||||
|---|---|---|---|---|---|
| Outcome | n/N (%) | IRR (95% CI) | p Value | IRR (95% CI) | p Value |
| Mortality | |||||
| Vitamin D insufficiency (<75 nmol/L) | 61/218 (28.0) | 0.73 (0.50 to 1.08) | 0.12 | 0.70 (0.47 to 1.04) | 0.08 |
| Adequate vitamin D | 43/126 (34.1) | ||||
| Vitamin D deficient (<50 nmol/L) | 20/55 (36.4) | 1.34 (0.82 to 2.18) | 0.25 | 0.91 (0.55 1.50) | 0.71 |
| Not deficient | 84/289 (29.1) | ||||
| Continuous vitamin D (nmol/L) | 1.00 (0.99 to 1.01) | 0.49 | 1.01 (1.00 to 1.02) | 0.15 | |
| HIV disease progression | |||||
| Vitamin D insufficiency (<75 nmol/L) | 46/150 (30.7) | 1.10 (0.67 to 1.82) | 0.71 | 1.08 (0.64 to 1.82) | 0.78 |
| Adequate vitamin D | 23/90 (25.6) | Reference | Reference | ||
| Vitamin D deficient (<50 nmol/L) | 14/34 (41.2) | 1.91 (1.05 to 3.44) | 0.03 | 1.48 (0.78 to 2.82) | 0.23 |
| Not deficient | 55/206 (26.7) | Reference | Reference | ||
| Continuous vitamin D (nmol/L) | 0.99 (0.98 to 1.01) | 0.30 | 1. 00 (0.99 to 1.01) | 0.57 | |
p Values obtained using Cox proportional hazards regression; IRR, incident rate ratio.
Multivariate analyses adjusted for age, Karnofsky score, baseline haemoglobin, viral load, HIV status, CD4 T-cell counts and micronutrient supplementation.