Univariate and multivariate analysis of the risk of de novo lung cancer
| Variables | Crude OR | 95% CI | p Value | Adjusted OR (all variables) | 95% CI | p Value | Adjusted OR (selected variables) | 95% CI | p Value |
|---|---|---|---|---|---|---|---|---|---|
| Sex | |||||||||
| Female | Reference | ||||||||
| Male | 2.088 | 0.787 to 5.540 | 0.139 | 0.946 | 0.343 to 2.608 | 0.914 | |||
| Age, per 1 year increase | 1.037 | 1.004 to 1.071 | 0.027 | 1.028 | 0.994 to 1.064 | 0.108 | 1.026 | 0.993 to 1.060 | 0.1196 |
| Smoking history, per 1 cigarette×year | 1.000 | 1.000 to 1.000 | 0.003 | 1.000 | 0.999 to 1.001 | 0.171 | |||
| BMI, per 1 unit increase | 1.007 | 0.996 to 1.018 | 0.231 | 1.008 | 0.993 to 1.024 | 0.288 | |||
| %FVC, per 1% increase | 1.001 | 0.989 to 1.013 | 0.845 | 1.007 | 0.989 to 1.024 | 0.462 | |||
| %FEV1, per 1% increase | 0.998 | 0.989 to 1.007 | 0.641 | 0.999 | 0.985 to 1.014 | 0.9153 | |||
| Emphysema | 2.602 | 1.324 to 5.116 | 0.006 | 1.513 | 0.681 to 3.363 | 0.309 | 2.055 | 1.042 to 4.053 | 0.038 |
| COPD | 2.367 | 1.171 to 4.785 | 0.016 | 1.125 | 0.439 to 2.887 | 0.806 | |||
| Asthma | 0.277 | 0.114 to 0.672 | 0.046 | 0.356 | 0.144 to 0.885 | 0.262 | 0.349 | 0.143 to 0.849 | 0.020 |
| Other RD | 0.731 | 0.379 to 1.409 | 0.350 | 0.835 | 0.408 to 1.710 | 0.622 | |||
BMI, body mass index; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; RD, respiratory diseases.