Table 3

Effect of ω-3 fatty acid supplementation on plasma t-PA activity concentrations.

Substance P, pmol/min	ω-3 Fatty acids				Placebo
Substance P, pmol/min	0	2	4	8	0	2	4	8
t-PA activity, IU mL⁻¹
Non-infused arm	0.39±0.08	0.45±0.09	0.54±0.12	0.64±0.14	0.45±0.07	0.52±0.08	0.60±0.09	0.65±0.11
Infused arm	0.38±0.08	0.83±0.16	1.12±0.23	1.67±0.38	0.43±0.07	0.78±0.10	1.09±0.11	1.26±0.15
t-PA antigen, ng mL⁻¹
Non-infused arm	11.78±1.29	12.01±1.0	12.69±1.08	12.83±1.49	13.45±1.40	12.93±1.70	13.08±1.80	12.37±1.27
Infused arm	11.90±1.45	13.98±1.33	13.63±1.12	14.86±1.40	12.55±1.10	12.85±1.44	13.45±1.35	13.97±1.55
PAI-1 activity, ng mL⁻¹
Non-infused arm	1.77±0.53	1.84±0.43	1.80±0.42	1.64±0.45	1.44±0.29	1.38±0.26	1.39±0.47	1.34±0.44
Infused arm	2.33±0.86	2.18±0.61	2.21±0.69	1.92±0.63	1.69±0.46	1.64±0.41	1.54±0.39	1.49±0.39
PAI-1 antigen, ng mL⁻¹
Non-infused arm	39.51±9.22	40.84±7.08	39.99±6.62	38.48±5.79	45.06±7.09	43.33±6.45	44.41±6.67	44.26±7.03
Infused arm	37.64±8.36	38.83±6.25	41.71±5.74	40.26±7.32	48.89±8.25	42.65±6.59	43.12±6.60	40.61±6.46
Net t-PA antigen release, ng 100 mL⁻¹ of tissue mm⁻¹	0.23±0.51	−0.28±4.7	3.92±1.8	8.41±2.94	−0.87±1.1	−0.84±2.82	0.94±4.22	8.10±3.67

Mean±SEM. Data analysed using two-way analysis of variance.
Tissue plasminogen activator (t-PA) activity: dose response p<0.0001. ω-3 Fatty acids versus placebo; p=0.83 (infused arm).
t-PA antigen: dose response p=0.7. ω-3 Fatty acids versus placebo; p=0.60 (infused arm).
Plasminogen-activator inhibitor type 1 (PAI-1) activity: dose response p=0.94. ω-3 Fatty acids versus placebo; p=0.17 (infused arm).
PAI-1 antigen: dose response p=0.67. ω-3 Fatty acids versus placebo; p=0.40 (infused arm).
Net t-PA antigen: dose response p=0.02. ω-3 Fatty acids versus placebo; p=0.62 (infused arm).