Incidence rate ratios (IRRs) for different types of suicidal or self-harming behaviour by risk period and antidepressant type: selective serotonin reuptake inhibitors (SSRIs) and tricyclic anti-depressants (TCAs)
| SSRIs | TCAs | |||||
|---|---|---|---|---|---|---|
| Suicide attempt 423 events* | Suicidal ideation 458 events* | Self-harm 654 events* | Suicide attempt 79 events* | Suicidal ideation 81 events* | Self-harm 118 events* | |
| Risk period | IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | IRR (95% CI) |
| Unexposed | 0.09 (0.07 to 0.13) | 0.07 (0.05 to 0.10) | 0.12 (0.09 to 0.17) | 0.20 (0.09 to 0.46) | 0.09 (0.05 to 0.18) | 0.15 (0.08 to 0.30) |
| Pre-exposure 1 (−4 months) | 0.19 (0.10 to 0.38) | 0.29 (0.15 to 0.54) | 0.37 (0.22 to 0.61) | 0.61 (0.18 to 2.10) | 0.15 (0.03 to 0.68) | 0.29 (0.08 to 1.03) |
| Pre-exposure 2 (−3 months) | 0.31 (0.17 to 0.53) | 0.45 (0.26 to 0.77) | 0.59 (0.38 to 0.90) | 0.29 (0.06 to 1.39) | 0.30 (0.10 to 0.90) | 0.09 (0.01 to 0.71) |
| Pre-exposure 3 (−2 months) | 0.62 (0.40 to 0.96) | 0.76 (0.48 to 1.19) | 0.65 (0.43 to 0.98) | 0.14 (0.02 to 1.16) | 0.21 (0.06 to 0.74) | 0.46 (0.16 to 1.33) |
| Pre-exposure 4 (−1 month) | Reference | Reference | Reference | Reference | Reference | Reference |
| Prescription day | 4.17 (2.44 to 7.12) | 33.41 (23.56 to 47.39) | 11.48 (7.93 to 16.62) | 8.82 (2.79 to 27.82) | 14.00 (6.81 to 28.75) | 3.47 (0.97 to 12.45) |
| Week 1 | 0.79 (0.40 to 1.55) | 0.38 (0.13 to 1.05) | 0.69 (0.35 to 1.35) | 1.18 (0.24 to 5.68) | 0.59 (0.13 to 2.59) | 0.77 (0.17 to 3.50) |
| Week 2 | 0.74 (0.39 to 1.42) | 0.57 (0.26 to 1.27) | 0.96 (0.55 to 1.68) | 1.02 (0.21 to 4.91) | 0.25 (0.03 to 1.91) | 0.33 (0.04 to 2.57) |
| Week 3 | 1.07 (0.61 to 1.86) | 1.56 (0.91 to 2.68) | 1.33 (0.82 to 2.19) | 0.53 (0.06 to 4.29) | 1.03 (0.34 to 3.13) | 1.01 (0.28 to 3.61) |
| Week 4 | 0.52 (0.24 to 1.15) | 0.98 (0.51 to 1.91) | 1.23 (0.73 to 2.07) | 0.57 (0.07 to 4.67) | 0.84 (0.24 to 2.94) | 0.37 (0.05 to 2.90) |
| Rest of AD episode | 0.53 (0.36 to 0.78) | 0.72 (0.49 to 1.08) | 0.64 (0.45 to 0.90) | 0.38 (0.11 to 1.33) | 0.52 (0.20 to 1.35) | 0.48 (0.18 to 1.25) |
| Washout 1 (+1 month) | 0.42 (0.25 to 0.69) | 0.40 (0.23 to 0.70) | 0.28 (0.16 to 0.48) | 0.66 (0.21 to 2.09) | 0.43 (0.16 to 1.11) | 0.09 (0.01 to 0.69) |
| Washout 2 (+2 months) | 0.17 (0.09 to 0.35) | 0.12 (0.06 to 0.29) | 0.32 (0.19 to 0.55) | 0.28 (0.06 to 1.33) | 0.27 (0.09 to 0.83) | 0.43 (0.15 to 1.25) |
| Washout 3 (+3 months) | 0.15 (0.09 to 0.25) | 0.20 (0.12 to 0.33) | 0.19 (0.12 to 0.31) | 0.41 (0.16 to 1.03) | 0.13 (0.06 to 0.27) | 0.35 (0.17 to 0.73) |
*Number of events in young people taking antidepressants. AD, antidepressant.