Table 3

Univariate correlations (Spearman's r) and multivariate regression analysis between the baseline variables age, MS duration, third ventricular width and Fatigue Scale for motor (FSMC m) and cognitive (FSMC c) function and the target variables of the motor and neuropsychological tests

Target variables	Baseline variables		3. Ven W	FSMC m or c	After multivariate regression analysis the target variable remained significantly correlated
	Age	MS dur

	r
	p Value
25-Foot Walk	0.30	0.18	0.38	0.43	3. Ven W (p=0.002), FSMC m (p=0.01)
25-Foot Walk	<0.05	ns	<0.005	<0.005
9HP dom hand	0.38	0.17	0.40	0.37	3. Ven W (p=0.002), FSMC m (p=0.004)
9HP dom hand	<0.005	ns	0.0001	<0.005
9HP non-dom hand	0.23	0.09	0.43	0.33	3. Ven W (p=0.002), FSMC m (p=0.0006)
9HP non-dom hand	0.06	ns	<0.0001	<0.008
SRT_{total recall}	−0.31	−0.12	−0.32	−0.20	3. Ven W (p=0.04)
SRT_{total recall}	0.01	ns	<0.0001	ns
SRT_{delayed recall}	−0.08	0.12	−0.05	−0.40	FSMC c (p=0.001)
SRT_{delayed recall}	ns	ns	ns	0.001
SPART_{total recall}	−0.11	−0.26	−0.21	−0.05	3. Ven W (p=0.005)
SPART_{total recall}	ns	0.03	0.08	ns
SPART_{delayed recall}	−0.37	0.09	−0.29	0.00	Age (p=0.003), 3 Ven W (p=0.03)
SPART_{delayed recall}	<0.005	ns	0.01	ns
SDMT	−0.42	−0.19	−0.43	−0.21	Age (p=0.008), 3 Ven W (p=0.008)
SDMT	<0.001	ns	<0.0005	0.08
PASAT 3 s	−0.15	0.09	−0.06	0.02
PASAT 3 s	ns	ns	ns	ns
PASAT 2 s	−0.22	0.08	−0.16	0.03
PASAT 2 s	ns	ns	ns	ns
WLG	−0.21	0.11	−0.03	−0.18
WLG	ns	ns	ns	ns
BDI	0.04	−0.07	0.02	0.67
BDI	ns	ns	ns	<0.0001
FSMC c	0.09	0.13	−0.01
FSMC c	ns	ns	ns
FSMC m	0.12	0.23	0.16		MS dur (p=0.04)
FSMC m	ns	0.06	ns
FSMC total	0.0	0.12	0.05
FSMC total	ns	ns	ns

Apart from age and MS duration (both in years) analysis with all other variables were performed using their respective z-values.
3 Ven W, third ventricle width; 9HP dom hand, 9-Hole PEG test of the dominant hand; 9HP non-dom hand, 9-Hole PEG test of the non-dominant hand; 25-Foot Walk, 25-Feet Foot Walk; BDI, Beck Depression Inventory; FSMC, Fatigue Scale for motor (m) and cognitive (c) function; MS dur, disease duration of multiple sclerosis; ns, not significant; PASAT, Paced Auditory Serial Addition Test (PASAT 2 s and 3 s version); r, Spearman's correlation coefficient; SDMT, Symbol Digit Modalities Test; SPART, Spatial Recall Test with a total and a delayed recall; SRT, Selective Reminding Test with a total and a delayed recall; WLG, Word List Generation Test.;