Risk Factors for MCI and AD from Logistic Regression Models
| MCI | AD | |||
|---|---|---|---|---|
| OR CI 95% | p Value | OR CI 95% | p Value | |
| Global effects | ||||
| X (+)† | 1.39 (0.93 to 2.06) | 0.104 | 1.18 (0.85 to 1.67) | 0.324 |
| P (+)‡ | 1.25 (0.82 to 1.90) | 0.293 | 1.26 (0.88 to 1.23) | 0.205 |
| SNP1-A§ | 1.14 (0.76 to 1.71) | 0.506 | 1.13 (0.78 to 1.62) | 0.510 |
| SNP2-A¶ | 1.05 (0.71 to 1.54) | 0.304 | 1.08 (0.77 to 1.51) | 0.649 |
| E4 (+)** | 2.44 (1.61 to 3.69) | <0.001 | 4.23 (2.93 to 6.12) | <0.001 |
| Women | 1.07 (0.73 to 1.56) | 0.705 | 1.67 (1.19 to 2.35) | 0.003 |
| E4 (+)*Women†† | 2.27 (1.32 to 3.87) | 0.003 | 4.85 (3.04 to 7.73) | <0.001 |
| E4 (+)*Men‡‡ | 2.74 (1.43 to 5.23) | 0.002 | 3.19 (1.73 to 5.88) | <0.001 |
| Independent effects | ||||
| X (+) E4(−)§§ | 1.04 (0.65 to 1.66) | 0.863 | 1.18 (0.76 to 1.81) | 0.452 |
| P (+) E4(−)§§ | 0.86 (0.52 to 1.40) | 0.545 | 1.19 (0.754 to 1.90) | 0.444 |
| SNP1-A(+)*E4(−)§§ | 1.19 (0.74 to 1.92) | 0.469 | 1.13 (0.73 to 1.76) | 0.568 |
| SNP2-A(+)*E4(−)§§ | 1.03 (0.65 to 1.66) | 0.879 | 1.07 (0.70 to 1.64 | 0.758 |
| ESR1 | ||||
| Combined effects | ||||
| E4(+)*X¶¶ | 3.17 (1.80 to 5.59) | <0.001 | 5.07 (3.00 to 8.55) | <0.001 |
| E4(+)*P¶¶ | 2.74 (1.55 to 4.85) | 0.001 | 5.35 (3.11 to 9.17) | <0.001 |
| E4(+)*SNP1-A¶¶ | 2.53 (1.31 to 4.90) | <0.001 | 4.44 (2.48 to 7.93) | <0.001 |
| ESR2 | ||||
| Combined effects | ||||
| E4(+)*SNP2-A¶¶ | 2.77 (1.55 to 4.93) | 0.001 | 4.87 (2.91 to 8.17) | <0.001 |
| Genetic profile (XPAA) | ||||
| Independent effects | ||||
| XPAA*E4(−)*** | 1.31 (0.48 to 3.54) | 0.590 | 1.19 (0.49 to 2.91) | 0.696 |
| XPAA(−)*E4(+)††† | 2.53 (1.61 to 3.93) | <0.001 | 4.32 (2.91 to 6.40) | <0.001 |
| Combined effects | ||||
| XPAA*E4(+)§§§ | 3.30 (1.28 to 8.54) | 0.014 | 5.16 (2.19 to 12.14) | <0.001 |
| XPAA*E4(+)*Women§§§ | 3.84 (1.09 to 13.57) | 0.036 | 8.04 (2.60 to 24.80) | <0.001 |
| XPAA*E4(+)*Men§§§ | 3.20 (0.73 to 14.11) | 0.124 | 3.57 (0.88 to 14.47) | 0.075 |
†Effect of sample with at least one X of RFLP XbaI.
‡Effect of sample with at least one P of RFLP PvuII.
§Effect of sample with at least one A allele of rs2228480.
¶Effect of sample with at least one A allele of rs4986938.
**Effect of sample with at least one E4 allele of the APOE gene.
††Women selected by at least one E4 allele of the APOE gene.
‡‡Men selected by at least one E4 allele of the APOE gene.
§§Sample selected by at least one allele that is indicated and the absence of the E4 allele of the APOE gene.
¶¶Sample selected by at least one E4 allele of the APOE gene and one of the alleles that is indicated. The reference category was sample control.
***Sample selected by absence of the E4 allele of the APOE gene and the presence of XPAA.
†††Sample selected by absence of XPAA and the presence by at least one E4 allele of the APOE gene. Sample selected by at least one E4 allele of the APOE gene and the presence XPAA.
‡‡‡Sample selected by at least one E4 allele of the APOE gene and the presence of XPAA.
§§§Women or men selected by at least one E4 allele of the APOE gene and the presence of XPAA. * In all models, the reference category was sample control considering the age and sex (as appropriate).