Table 4

Association of baseline markers with treatment response measured by change in DAS28 from baseline at week 16

All association results for primary DNA markers
Gene	SNP	All DMARD-IR, TCZ					White DMARD-IR, TCZ
Gene	SNP	MAF	n	β	SE	Raw P	MAF	n	β	SE	Raw P
IL-6	rs12700386	0.19	583	0.22	0.11	0.049	0.18	468	0.16	0.13	0.20
	rs2069833	0.35	584	−0.08	0.08	0.34	0.42	469	−0.13	0.09	0.18
	rs2069837	0.08	586	−0.11	0.15	0.44	0.08	471	−0.05	0.16	0.75
	rs2066992	0.12	586	−0.09	0.12	0.49	0.06	471	−0.11	0.21	0.61
	rs2069840	0.32	584	0.24	0.09	0.007	0.33	469	0.30	0.10	0.0026
	rs1554606	0.4	586	−0.10	0.08	0.23	0.45	471	−0.15	0.09	0.12
	rs2069845	0.4	583	−0.10	0.08	0.23	0.45	468	−0.15	0.09	0.12
	rs2069861	0.07	584	−0.10	0.15	0.53	0.08	469	−0.11	0.16	0.50
	rs10242595	0.36	586	−0.02	0.08	0.86	0.32	471	−0.02	0.10	0.80
	rs11766273	0.07	586	0.10	0.16	0.53	0.08	471	0.05	0.17	0.75
IL-6R	rs1386821	0.15	586	0.02	0.12	0.87	0.17	471	0.06	0.13	0.67
	rs4075015	0.39	584	−0.06	0.09	0.50	0.41	469	−0.07	0.10	0.46
	rs6684439	0.41	586	0.03	0.08	0.76	0.39	471	0.06	0.10	0.55
	rs4845618	0.43	582	0.03	0.08	0.74	0.44	467	0.00	0.09	0.99
	rs8192282	0.15	581	−0.09	0.12	0.46	0.16	468	−0.08	0.13	0.53
	rs7549250	0.43	575	0.07	0.08	0.43	0.44	462	0.02	0.09	0.81
	rs4553185	0.43	586	0.04	0.08	0.60	0.44	471	0.01	0.09	0.90
	rs4845623	0.44	586	−0.01	0.08	0.92	0.41	471	0.01	0.10	0.89
	rs4537545	0.44	586	−0.04	0.08	0.60	0.41	471	−0.01	0.10	0.93
	rs4129267	0.41	586	−0.02	0.08	0.77	0.4	471	0.02	0.10	0.87
	rs8192284	0.41	582	−0.03	0.08	0.76	0.4	467	0.02	0.10	0.87
	rs11265618	0.17	586	−0.05	0.11	0.64	0.17	471	−0.04	0.13	0.73
	rs4329505	0.16	582	−0.03	0.11	0.81	0.16	467	−0.02	0.13	0.87
	rs4240872	0.24	586	0.03	0.10	0.79	0.23	471	−0.01	0.11	0.93
	rs4509570	0.24	580	0.02	0.10	0.85	0.23	466	−0.02	0.11	0.83
	rs2229238	0.19	584	−0.03	0.11	0.75	0.19	469	0.00	0.12	0.98
	rs7514452	0.19	586	−0.03	0.11	0.77	0.19	471	0.00	0.12	0.98
	rs7526293	0.2	584	−0.04	0.10	0.71	0.2	469	−0.03	0.12	0.79

DNA markers analysed in the pooled DMARD-IR population with an FDR* of <0.1
Tiers	Gene	SNP	Population	MAF	n	β	SE	RAW P	FDR P
1	IL-6	rs2069840	White	0.33	469	0.30	0.10	0.0026	0.073
3	PTPN2	rs973767	All white	0.14	586	0.48	0.12	7.2E-05	0.072
3	PTPN2	rs973767	All white	0.16	471	0.53	0.13	5.7E-05	0.057

Baseline DAS28 and TCZ dose were included in the model as covariates.
*FDR was calculated within the white or all population and within the tier.
β, regression coefficient, representing the difference in DAS28 corresponding to each SD in marker value; DAS28, Disease Activity Score using 28 joints; DMARD, disease-modifying antirheumatic drug; FDR, false discovery rate; IL-6, interleukin-6; IL-6R, IL-6 receptor; IR, inadequate responder; MAF, minor allele frequency; SNP, single nucleotide polymorphism; TCZ, tocilizumab.