Table 3

MI HRs for hormone therapy in subgroups defined by participant characteristics associated with hormone exposure

Subgroup within dataset	Dataset
Subgroup within dataset	RCTs for HT		RCT for diet		WHI OS
	MI HR for HT in the subgroup of the indicated dataset (Numbers in parentheses are HRs for E+P and E-alone)
		95% CI		95% CI		95% CI
All participants	1.18 (1.30,1.05)	0.99 to 1.41	0.75 (0.95,0.65)	0.62 to 0.89	0.83 (0.86, 0.80)	0.72 to 0.95
Age
50–59	1.25 (1.63,0.69)	0.80 to 1.96	0.57 (0.73,0.44)	0.37 to 0.89	0.73 (0.74,0.60)	0.54 to 0.99
60–69	1.01 (1.05,0.95)	0.78 to 1.32	0.73 (0.88,0.65)	0.56 to 0.94	0.87 (0.97,0.81)	0.71 to 1.07
70–79	1.46 (1.46,1.20)	0.99 to 2.15	0.87 (1.33,0.74)	0.65 to 1.18	0.84 (0.75,0.86)	0.68 to 1.03
Years since meno
<10	1.03 (1.14,0.77)	0.73 to 1.46	0.83 (1.01,0.68)	0.60 to 1.15	0.85 (0.94,0.80)	0.73 to 0.99
10–19	0.95 (1.06,0.74)	0.68 to 1.34	0.67 (0.95,0.47)	0.48 to 0.95	0.77 (0.74,0.72)	0.44 to1.35
>19	1.41 (1.77,1.23)	1.08 to 1.85	0.69 (0.60,0.70)	0.50 to 0.93	1.35 (0.61,1.28)	0.46 to 3.96
HT after baseline			No data		0.71 (0.76, 0.72)	0.57 to 0.88
Follow-up for RCT
End 3 years after enrolment	1.26 (1.45,1.06)	1.00 to 1.58			0.86 (0.87,0.85)	0.71 to 1.02
Begin 3 years after enrolment	1.08 (1.11,1.04)	0.82 to 1.41			0.79 (0.84,0.73)	0.64 to 0.97
Previous use of HT
No	1.07 (0.96,1.20)	0.86 to 1.32
Yes	1.51 (1.12,1.46)	1.09 to 2.08
Propensity score
<0.25	1.26 (1.27,1.18)	0.96 to 1.66	0.75 (0.76, 0.71)	0.48 to 1.17	0.98 (1.04,0.83)	0.72 to 1.34
0.25–0.75	1.11 (1.32,1.02)	0.87 to 1.42	0.80 (1.01, 0.69)	0.64 to 1.00	0.85 (0.81, 0.86)	0.72 to 1.01
>0.75	1.05 (NA, 0.93)	0.42 to 2.64	0.69 (1.08, 0.67)	0.34 to 1.40	0.76 (0.96, 0.74)	0.45 to 1.27

E-alone, oestrogen alone; E+P, oestrogen plus progestin; HT, hormone therapy; meno, menopause; MI, myocardial infarction; NA, not available because only one MI case in this group; OS, observational study; RCT, randomised controlled trial; WHI, Women's Health Initiative.