Table 2

CanDECIDE study secondary objectives and statistical analysis plans

ObjectivesOutcomeIndependent variablesHypothesesStatistical analysis
Secondary determination of role of

  1. Diet

  2. Physical activity

  3. Adiposity

  4. Sleep

  5. Stress

  6. Built environment

That impacts circulating cytokine levels, gene expression and DNA methylation patterns of TLR and cytokine genes in obese survivors of childhood brain tumours and comparing them with non-obese tumour survivors and lean and obese patients with no history of tumours		Understand the role of

  1. Diet

  2. Physical activity

  3. Adiposity

  4. Sleep

  5. Stress

  6. Built environment

On development of inflammation in obese survivors of childhood cancer and comparing them with non-obese tumour survivors and lean and obese patients with no history of tumours

  1. Age

  2. Sex

  3. Ethnicity

  4. Puberty

  5. Physical activity

  6. Tumour type

  7. Tumour location

  8. Tumour treatment

  9. Hormonal deficiencies

  10. BMI

  11. Lipid levels

  12. HOMA-IR

 Obese survivors of childhood brain tumours have higher inflammatory status and altered gene methylation patterns, and this is mediated via individual and lifestyle factors Descriptive analysis Regression

  • BMI, body mass index; CanDECIDE,Canadian Study of Determinants of Endometabolic Health in ChIlDrEn; TLR, Toll-like receptor.