Antitubercular activity and selectivity of synthetic IBP derivatives (10–16)
| MIC values against Mycobacterium (mg/L) | ||||
|---|---|---|---|---|
| M tuberculosis H37RV | M bovis BCG | Cytotoxicity GIC50 (mg/L) RAW264.7 | Selectivity index SI (GIC50 /MIC) | |
| 10 | >100 | >100 | 750 | <7.5 |
| 11 | >100 | 100 | 325 | <3.25 |
| 12 | 40 | 60 | 100 | 2.5 |
| 13 | 90 | 80 | 200 | 2.2 |
| 14 | >100 | >100 | Nd | Nd |
| 15 | 30 | 50 | 400 | 13.3 |
| 16 | 40 | >100 | 250 | 6.25 |
IBP, ibuprofen; MIC, minimum inhibitory concentration; Nd, not determined.