Results of memory testing, neuroimaging and CSF investigations
| Participants with stable MCI vs MCI participants progressing to AD Prior probability of correct classification, before any testing: 44.8%* | |||||||
|---|---|---|---|---|---|---|---|
| MCI stable n=100 | MCI progression n=81 | ||||||
| True negative | False positive | True positive | False negative | Posterior probability (%) | NRI (%) | 95% CI NRI | |
| Memory testing with RAVLT | 48 | 52 | 71 | 10 | 65.7 | 21.0 | 15.1 to 26.9 |
| MRI entorhinal cortex volumetry | 72 | 28 | 49 | 32 | 66.9 | 22.1 | 16.1 to 28.1 |
| CSF p-τ/Aβ ratio | 49 | 51 | 66 | 15 | 63.5 | 18.8 | 13.1 to 24.5 |
*The prior probability of correct classification is calculated assuming that all participants progress from mild cognitive impairment (MCI) to AD.
AD, Alzheimer's disease; CSF, cerebrospinal fluid; NRI, net reclassification improvement.