Site-specific problems
| Potential problems | Severity of problem | Trial | Hospital type | Role type | ||||
|---|---|---|---|---|---|---|---|---|
| HOPON (n=27) | PET-Neck (n=31) | SEND (n=27†) | DGH (n=44) | Teaching hospital (n=41†) | Medical practitioners (n=49†) | Research nurses (n=22) | ||
| R&D delays | No problem | 18 (67) | 18 (58) | 21 (81) | 26 (59) | 31 (78) | 28 (58) | 15 (68) |
| Mild | 7 (26) | 8 (26) | 4 (15) | 12 (27) | 7 (18) | 12 (25) | 7 (32) | |
| Moderate | 2 (7) | 3 (10) | 0 (0) | 3 (7) | 2 (5) | 5 (10) | 0 (0) | |
| Severe | 0 (0) | 2 (6) | 1 (4) | 3 (7) | 0 (0) | 3 (6) | 0 (0) | |
| p Value* | 0.16 | 0.17 | 0.07 | |||||
| Delays in local approval by Trust Research Board | No problem | 19 (70) | 24 (77) | 20 (77) | 32 (73) | 31 (78) | 29 (60) | 20 (91) |
| Mild | 4 (15) | 4 (13) | 4 (15) | 4 (9) | 8 (20) | 11 (23) | 1 (5) | |
| Moderate | 3 (11) | 2 (6) | 2 (8) | 6 (14) | 1 (3) | 6 (13) | 1 (5) | |
| Severe | 1 (4) | 1 (3) | 0 (0) | 2 (5) | 0 (0) | 2 (4) | 0 (0) | |
| p Value* | 0.75 | 0.29 | 0.02 | |||||
| Research nurse/practitioner not available | No problem | 12 (44) | 21 (68) | 18 (69) | 27 (61) | 24 (60) | 25 (52) | 16 (73) |
| Mild | 9 (33) | 6 (19) | 1 (4) | 11 (25) | 5 (13) | 10 (21) | 3 (14) | |
| Moderate | 2 (7) | 4 (13) | 1 (4) | 2 (5) | 5 (13) | 5 (10) | 1 (5) | |
| Severe | 4 (15) | 0 (0) | 6 (23) | 4 (9) | 6 (15) | 8 (17) | 2 (9) | |
| p Value* | 0.23 | 0.95 | 0.26 | |||||
| Problems with availability of required technology† | No problem | 21 (78) | 16 (52) | NA§ | ||||
| Mild | 3 (11) | 12 (39) | ||||||
| Moderate | 1 (4) | 2 (6) | ||||||
| Severe | 2 (7) | 1 (3) | ||||||
| p Value* | NA§ | NA§ | NA§ | |||||
| Problems with funding for required technology‡ | No problem | 15 (55) | 19 (61) | NA§ | ||||
| Mild | 4 (15) | 6 (19) | ||||||
| Moderate | 1 (4) | 4 (13) | ||||||
| Severe | 7 (26 | 2 (6) | ||||||
| P Value* | NA§ | NA§ | NA§ | |||||
| Lack of places on a GCP course locally | No problem | 20 (74) | 26 (84) | 22 (85) | 34 (77) | 34 (85) | 38 (79) | 18 (82) |
| Mild | 6 (22) | 5 (16) | 3 (12) | 10 (23) | 4 (10) | 8 (17) | 4 (18) | |
| Moderate | 1 (4) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
| Severe | 0 (0) | 0 (0) | 1 (4) | 0 (0) | 2 (5) | 2 (4) | 0 (0) | |
| p Value* | 0.54 | 0.33 | 0.98 | |||||
*p Value from ordinal logistic regression model (adjusted for trial in hospital type and role type analyses).
†One missing response.
‡Hyperbaric oxygen, PET imaging or ARSAC licence (trial specific question).
§NA as question excluded from SEND trial as not relevant.
DGH, district general hospital; GCP course, Good Clinical Practice course; HOPON, Hyperbaric Oxygen in the Prevention of Osteoradionecrosis; R&D delays, research and development delays; SEND, Selective Elective Neck Dissection.