Incidence of adverse events (AEs) in relation to the analgesic used
| AEs | Diclofenac n=913 | Ibuprofen n=722 | Aspirin n=141 | Other analgesics n=175 | ||||
|---|---|---|---|---|---|---|---|---|
| Low dose n=693 number of reports (%)* | High dose n=220 number of reports (%) | Low dose n=410 number of reports (%) | High dose n=312 number of reports (%) | Low dose n=102 number of reports (%) | High dose n=39 number of reports (%) | Low dose n=107 number of reports (%) | High dose n=68 number of reports (%) | |
| Urine blood | 6 (1) | 5 (2) | 5 (1) | 45 (14) | 7 (7) | 19 (49) | 1 (1) | 1 (2) |
| GI-cramp | 16 (2) | 5 (2) | 52 (13) | 89 (29) | 11 (11) | 9 (23) | 4 (4) | 9 (13) |
| GI-bleeding | 2 (<1) | 8 (4) | 13 (3) | 39 (13) | 9 (9) | 19 (49) | 1 (1) | 2 (3) |
| CV—during race | 2 (<1) | 0 (0) | 40 (10) | 28 (9) | 3 (3) | 8 (21) | 5 (5) | 0 (0) |
| CV—post race | 4 (1) | 8 (4) | 44 (11) | 97 (31) | 11 (11) | 12 (31) | 3 (3) | 3 (4) |
| Total (individuals)† | 25 | 22 | 56 | 163 | 25 | 34 | 11 | 12 |
| Drug related AE incidence | 4% | 10% | 14% | 52% | 25% | 87% | 10% | 18% |
*Percentages relate to the corresponding subpopulations and are rounded to the nearest whole number.
†Number of individuals reporting AEs (a single individual may report >1 AE).
See online supplementary table S2 for definition of dose sizes.
CV, cardiovascular; GI, gastrointestinal.