Influence of maternal HIV status on placental transfer of specific antibody
| Median placental transfer (IQR)* | Per cent reduction† | p Value‡ | ||
|---|---|---|---|---|
| HIV-infected mother: HIV-exposed, uninfected infant pairs (n=12) | HIV-uninfected mother: HIV-unexposed infant pairs (n=96) | |||
| Hib | 0.29 (0.13–0.39) | 0.74 (0.45–1.14) | 61 | 0.0004 |
| Pertussis | 0.75 (0.66–0.95) | 1.44 (1.04–1.87) | 48 | 0.0002 |
| Pneumococcus | 0.73 (0.61–0.98) | 1.02 (0.74–1.33) | 28 | 0.0033 |
| Tetanus | 0.92 (0.51–1.46) | 1.35 (1.00–1.75) | 32 | 0.0036 |
*Placental transfer of mother to infant is expressed as ratio of infant-specific/maternal-specific IgG concentration at birth.
†Reduction in placental transfer between HIV-infected and HIV-uninfected women and their infants, calculated as (1—ratio of the placental transfer from HIV-infected women/placental transfer from HIV-uninfected women)×100
‡Mann-Whitney U test.