Characteristics of included studies
| Study, year of publication | Country where study was conducted | Sample size (% male) | Age (Mean (SD)) | Study design | Duration of intervention | Long-acting formulation generation | Relevant outcomes | Rating scale(s) used for core symptoms |
|---|---|---|---|---|---|---|---|---|
| Whitehouse, 1980 | USA | 30 (83) | 8.5* | Parallel | 14 days | 1st generation | Core symptoms: Inattention Hyperactivity Hyperactivity/Impulsivity Adverse events | (i) Parent-Rating Scale† (ii) Teacher-Rating Scale† |
| Pelham, 1987 | USA | 13 (100) | 8.8 (1.5) | Crossover | Not reported | 1st generation | Adverse events | N/A |
| Pelham, 1990 | USA | 22 (100) | 10.39 (1.38) | Crossover | 3–6 days | 1st generation | Adverse events | N/A |
| Fitzpatrick, 1992 | USA | 19 (89) | 8.72 (1.33) | Crossover | 14 days/period | 1st generation | (i) Core symptoms: Hyperactivity Inattention/overactivity (ii) Adverse events | (i) IOWA Conners’ Parent Rating Scale (ii) IOWA Conners’ Teacher Rating Scale |
| Pelham, 2001 | USA | 70 (89) | 9.1(1.6) | Crossover | 7 days/period | OROS | (i) Core symptoms: Inattention/overactivity (ii) Adverse events | (i) IOWA Conners’ Parent Rating Scale (ii) IOWA Conners’ Teacher Rating Scale |
| Wolraich, 2001 | USA | 192 (82) | 9.0(1.8) | Parallel | 28 days | OROS | (i) Core symptoms: Inattention Inattention/overactivity Hyperactivity/impulsivity (ii) Adverse events | (i) IOWA Conners’ Parent Rating Scale (ii) IOWA Conners’ Teacher Rating Scale (iii) Parent SNAP-IV (iv) Teacher SNAP-IV |
| Dopfner, 2004 | Germany | 79 (90) | 10(1.6) | Crossover | 4–6 days/period | 2nd generation | Core symptoms: Inattention Hyperactivity/impulsivity | FBB-HKS Teacher Rating Scale |
| Findling, 2006 | Australia, Canada, USA | 272 (80) | 9.5(1.73) | Parallel | 21 days | 2nd generation | (i) Core symptoms: Inattention/overactivity (ii) Adverse events | (i) IOWA Conners’ Parent Rating Scale (ii) IOWA Conners’ Teacher Rating Scale |
| Gau, 2006 | Taiwan | 64 (91) | 10.5(3.2) | Parallel | 28 days | OROS | (i) Core symptoms: Inattention Hyperactivity/impulsivity(ii) Adverse events | (i) Chinese version of the Conners’ Parent Rating Scale Revised (ii) Chinese version of the Conners’ Teacher Rating Scale Revised |
| Steele, 2006 | Canada | 145 (83) | 8.25(2.1) | Parallel | 56 days | OROS | (i) Core symptoms: Inattention/Overactivity (ii) Adverse events | IOWA Conners’ Parent Rating Scale |
| Quinn, 2007 | Canada | 18 (72) | 9.6(2.5) | Crossover | 1 day/period | 2nd generation | Adverse events | N/A |
| Weiss, 2007 | Canada | 90 (91) | 11(2.5) | Crossover | 14 days/period | 2nd generation | (i) Core symptoms: Inattention Hyperactivity (ii) Adverse events | (i) Conners’ Parent Scale Revised (ii) Conners’ Teacher Scale Revised |
| Schachar, 2008 | Canada | 17 (88) | 11.3(2.2) | Crossover | 7 days/period | 2nd generation | (i) Core symptoms: Inattention/overactivity (ii) Adverse events | IOWA-C‡ |
*No SD reported.
†Study did not specify which scales were used.
‡Study did not specify who completed the questionnaire.
IOWA-C, Inattention/Overactivity with Aggression Conners’ scale; N/A, not applicable; OROS, osmotic release oral system.