Sensitivity analysis
| SC | SOD | SDD | ICER analyses SC vs SOD | ICER analyses SC vs SDD | ICER analyses SDD vs SOD | |
|---|---|---|---|---|---|---|
| Sensitivity analysis discounting effects (life years lost) | ||||||
| BC+1.5% | 4.27 (3.96 to 4.57) | 4.02 (3.72 to 4.32) | 4.23 (3.94 to 4.53) | SC=dominated by SOD | SC=dominated by SDD | SDD=dominated by SOD |
| +0% | 6.07 (5.58 to 6.55) | 5.62 (5.15 to 6.08) | 5.97 (5.50 to 6.44) | SC=dominated by SOD | SC=dominated by SDD | SDD=dominated by SOD |
| +3% | 2.82 (2.63 to 3.01) | 2.68 (2.49 to 2.87) | 2.82 (2.63 to 3.00) | SC=dominated by SOD | SC=dominated by SDD | SDD=dominated by SOD |
| Sensitivity analysis mechanical ventilation† | ||||||
| BC+15% | €41940.79 (€40183.93 to €43697.66) | €40433.42 (€38837.50 to €42029.35) | €41183.12 (€39408.39 to €42957.85) | SC=dominated by SOD | SC=dominated by SDD | SDD=dominated by SOD |
| +0% | €38715.73 (€37112.32 to €40319.14) | €37117.07 (€35659.90 to €38574.24) | €37874.94 (€36270.73 to €39479.15) | SC=dominated by SOD | SC=dominated by SDD | SDD=dominated by SOD |
| +30% | €45165.85 (€43251.01 to €47080.69) | €43749.78 (€42010.47 to €45489.09) | €44491.30 (€42542.03 to €46440.57) | SC=dominated by SOD | SC=dominated by SDD | SDD=dominated by SOD |
| Sensitivity analysis price study regimen*,† | €41940.79 (€40183.93 to €43697.66) | €40493.15 (€38996.62 to €42189.67) | €42720.23 (€40943.82 to €44.496.65) | SC=dominated by SOD | ICER 21590 | SDD=dominated by SOD |
*Price SOD €40 and SDD €400 per day.
†Effects are discounted 1.5% a year.
BC, base case results; ICER, incremental costs effectiveness ratio (costs/LYG); SC, standard care; SDD, Selective Decontamination of the Digestive tract, SOD, Selective Oropharyngeal Decontamination.