Reproductive hormones levels in Faroese and Danish men
| Faroese men (F1) | Faroese men (F2) | p Value* | Faroese men (F1+F2) | Danish men (D) | p Value* | |
|---|---|---|---|---|---|---|
| 2007–2009 (N=241) | 2009–2010 (N=240) | 2007–2010 (N=481) | 2006–2010 (N=1274) | |||
| FSH (IU/l) | ||||||
| Mean (SD) | 4.1 (4.7) | 3.4 (1.9) | 3.8 (3.6) | 2.8 (1.8) | ||
| Median (5–95 percentile) | 3.1 (1.3–8.5) | 2.9 (1.1–7.0) | 0.05 | 3.1 (1.2–7.7) | 2.5 (1.0–6.0) | <0.0005 |
| Inhibin B (pg/ml) | ||||||
| Mean (SD) | 196 (79) | 220 (84) | 208 (82) | 189 (70) | ||
| Median (5–95 percentile) | 192 (76–333) | 210 (99–382) | 0.04 | 202 (85–346) | 180 (90–318) | 0.05 |
| Inhibin B/FSH | ||||||
| Mean | 80 (72) | 101 (107) | 91 (92) | 100 (89) | ||
| Median (5–95 percentile) | 57 (11–203) | 70 (17–289) | 0.02 | 64 (13–259) | 76 (17–272) | <0.0005 |
| LH (IU/l) | ||||||
| Mean (SD) | 4.8 (2.4) | 4.8 (1.8) | 4.8 (2.1) | 3.5 (1.5) | ||
| Median (5–95 percentile) | 4.5 (2.1–8.5) | 4.6 (2.1–7.9) | 1.0 | 4.5 (2.1–7.9) | 3.3 (1.6–6.3) | <0.0005 |
| Testosterone (nmol/l) | ||||||
| Mean (SD) | 21 (7) | 23(7) | 22 (7) | 20 (6) | ||
| Median (5–95 percentile) | 20 (11–32) | 22 (14–36) | 0.006 | 21 (12–33) | 19 (12–31) | <0.0005 |
| Testosterone/LH | ||||||
| Mean | 5.0 (2.3) | 5.9 (7.2) | 5.5 (5.3) | 6.5 (2.8) | ||
| Median (5–95 percentile) | 4.6 (1.9–9.1) | 4.6 (2.7–11.6) | 0.09 | 4.6 (2.2–9.4) | 6.0 (3.0–12.0) | <0.0005 |
| Free testosterone (pmol/l) | ||||||
| Mean | 409 (134) | 462 (140) | 439 (134) | 454 (142) | ||
| Median (5–95 percentile) | 397 (211–633) | 442 (262–707) | <0.0005 | 424 (236–686) | 432 (269–701) | 0.1 |
| Free testosterone/LH | ||||||
| Mean | 99 (44) | 125 (175) | 112 (128) | 149 (71) | ||
| Median (5–95 percentile) | 92 (39–186) | 96 (49–212) | 0.03 | 94 (47–201) | 134 (65–273) | <0.0005 |
| Oestradiol (nmol/l) | ||||||
| Mean (SD) | 79 (22) | 96 (23) | 88 (24) | 80 (24) | ||
| Median (5–95 percentile) | 78 (46–113) | 94 (62–140) | <0.0005 | 86 (54–131) | 78 (48–125) | <0.0005 |
| Testosterone/oestradiol | ||||||
| Mean | 268 (83) | 243 (69) | 255 (78) | 258 (70) | ||
| Median (5–95 percentile) | 262 (140–409) | 236 (146–375) | <0.0005 | 243 (145–394) | 249 (175–383) | 0.1 |
| Free testosterone/oestradiol | ||||||
| Mean | 5332 (1567) | 4955 (1187) | 5143 (1400) | 5869 (1768) | ||
| Median (5–95 percentile) | 5218 (3230–7768) | 4876 (3165–7201) | 0.002 | 5026 (3182–7538) | 5636 (3519–8956) | <0.0005 |
| SHBG (nmol/l) | ||||||
| Mean (SD) | 38 (15) | 37 (15) | 38 (15) | 30 (12) | ||
| Median (5–95 percentile) | 36 (17–62) | 35 (19–68) | 0.7 | 36 (18–65) | 29 (14–51) | <0.0005 |
| Time of blood sampling | ||||||
| Mean (SD) | 11 : 56 (2 : 11) | 9 : 57 (1 : 29) | 10 : 27 (1 : 56) | 10 : 04 (0 : 42) | ||
| Median (5–95 percentile) | 10 : 15 (8 : 40–15 : 40) | 9 : 37 (8 : 02–12.45) | <0.0005† | 10 : 10 (8 : 30–15 : 00) | 10 : 00 (9 : 05–11 : 20) | 0.6† |
*Regression analysis adjusting for hour of day of blood sampling.
†Mann-Whitney test.
FSH, follicle-stimulating hormone; LH, luteinising hormone; SHBG, sex hormone-binding globulin.