Baseline characteristics of 529 CRC patients by quartiles of the three major dietary patterns
| Processed meat pattern | Prudent vegetable pattern | High-sugar pattern | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Q1 (n=132) | Q2 (n=132) | Q3 (n=133) | Q4 (n=132) | p Value* | Q1 (n=132) | Q2 (n=132) | Q3 (n=133) | Q4 (n=132) | p Value* | Q1 (n=132) | Q2 (n=132) | Q3 (n=133) | Q4 (n=132) | p Value* | |
| Age at diagnosis† | 61.4±8.7 | 60.6±9.0 | 60.2±8.8 | 59.3±9.3 | 0.29 | 57.4±10.3 | 60.1±7.9 | 61.0±9.0 | 62.1±8.0 | <.0001 | 59.5±9.3 | 60.2±9.1 | 60.0±8.8 | 61.7±8.6 | 0.21 |
| Sex† | |||||||||||||||
| Female | 67 (50.8) | 66 (50.0) | 39 (29.3) | 39 (29.6) | 38 (28.8) | 39 (29.5) | 58 (43.6) | 76 (57.6) | 60 (45.5) | 49 (37.1) | 51 (38.3) | 51 (38.6) | |||
| Male | 65 (49.2) | 66 (50.0) | 94 (70.7) | 93 (70.5) | <.0001 | 94 (71.2) | 93 (70.5) | 75 (56.4) | 56 (42.4) | <.0001 | 72 (54.5) | 83 (62.9) | 82 (61.7) | 81 (61.4) | 0.50 |
| Stage at diagnosis | |||||||||||||||
| I/II | 87 (65.9) | 81 (61.4) | 70 (52.6) | 71 (53.8) | 72 (54.5) | 71 (53.8) | 83 (62.4) | 83 (62.9) | 79 (59.8) | 77 (58.3) | 77 (57.9) | 76 (57.6) | |||
| III/IV | 45 (34.1) | 51 (38.6) | 63 (47.4) | 61 (46.2) | 0.09 | 60 (45.5) | 61 (46.2) | 50 (37.6) | 49 (37.1) | 0.27 | 53 (40.2) | 55 (41.7) | 56 (42.1) | 56 (42.4) | 0.98 |
| BMI (kg/m2) | |||||||||||||||
| <25.0 | 38 (30.6) | 47 (36.1) | 35 (26.5) | 27 (21.1) | 42(33.6) | 32(24.8) | 34(26.4) | 38(29.7) | 33(25.6) | 40(31.0) | 36(28.1) | 38(29.7) | |||
| 25.0–29.9 | 57 (46.0) | 52 (40.0) | 53 (40.2) | 53 (41.4) | 45 ( (35.2) | 57 (44.2) | 55 (42.6) | 58 (45.3) | 55 (42.6) | 47 (36.4) | 58 (45.3) | 55 (43.0) | |||
| ≥30 | 29 (23.4) | 31 (23.9) | 44 (33.3) | 48 (37.5) | 0.03 | 40 (31.2) | 40 (31.0) | 40 (31.0) | 32 (25.0) | 0.78 | 41 (31.8) | 42 (32.6) | 34 (26.6) | 35 (27.3) | 0.63 |
| Physical activity | |||||||||||||||
| <24.9 MET h/week | 73 (55.3) | 71 (53.4) | 56 (42.1) | 65 (49.2) | 68 (51.5) | 60 (45.4) | 69 (51.9) | 68 (51.5) | 68 (51.5) | 71 (53.8) | 69 (51.9) | 57 (43.2) | |||
| ≥24.9 MET h/week | 59 (44.7) | 61 (46.6) | 77 (57.9) | 67 (50.8) | 0.13 | 64 (48.5) | 72 (54.6) | 64 (48.1) | 64 (48.5) | 0.67 | 64 (48.5) | 61 (46.2) | 64 (48.1) | 75 (56.8) | 0.32 |
| Marital status | |||||||||||||||
| Single | 31 (23.5) | 29 (22.0) | 18 (13.5) | 37 (28.0) | 26 (19.7) | 27 (20.4) | 27 (20.3) | 35 (26.5) | 26 (19.7) | 30 (22.7) | 30 (22.6) | 29 (22.0) | |||
| Married or living as married | 101 (76.5) | 103 (78.0) | 115 (86.5) | 95 (72.0) | 0.04 | 106 (80.3) | 105 (79.6) | 106 (79.7) | 97 (73.5) | 0.50 | 106 (80.3) | 102 (77.3) | 103 (77.4) | 103 (78.0) | 0.93 |
| Smoking status | |||||||||||||||
| Ever | 77 (58.3) | 94 (71.2) | 113 (85.0) | 104 (78.8) | 108 (81.8) | 97 (73.5) | 100 (75.2) | 83 (62.9) | 101 (76.5) | 95 (72.0) | 95 (71.4) | 97 (73.5) | |||
| Never | 55 (41.7) | 38 (28.8) | 20 (15.0) | 28 (21.2) | <.0001 | 24 (18.2) | 35 (26.5) | 33 (24.8) | 49 (37.1) | 0.006 | 31 (23.5) | 37 (28.0) | 38 (28.6) | 35 (26.5) | 0.79 |
| Tumour location | |||||||||||||||
| Colon | 91 (69.5) | 90 (68.2) | 85 (63.9) | 79 (59.9) | 75(56.8) | 91(69.5) | 87(65.4) | 92(69.7) | 82(62.1) | 85(64.9) | 87(65.4) | 91(68.9) | |||
| Rectum | 40(30.5) | 42(31.8) | 48(36.1) | 53(40.1) | 0.34 | 57(43.2) | 40 (30.5) | 46 (34.6) | 40 (30.3) | 0.10 | 50 (37.9) | 46 (35.1) | 46 (34.6) | 41 (31.1) | 0.71 |
| Reported chemoradiotherapy | |||||||||||||||
| Yes | 36 (27.3) | 31 (23.5) | 20 (15.0) | 21 (15.9) | 24 (18.2) | 23 (17.4) | 24 (18.1) | 37 (28.0) | 30 (22.7) | 28 (21.2) | 25 (18.8) | 25 (18.9) | |||
| No | 96 (72.7) | 101 (76.5) | 113 (85.0) | 111 (84.1) | 0.04 | 108 (81.8) | 109 (82.6) | 109 (81.9) | 95 (72.0) | 0.10 | 102 (77.3) | 104 (78.8) | 108 (81.2) | 107 (81.1) | 0.83 |
| MSI status | |||||||||||||||
| MSS/MSI-L | 108 (86.4) | 110 (86.6) | 113 (91.9) | 106 (86.9) | 107 (85.6) | 104 (86.7) | 113 (91.1) | 113 (88.3) | 107 (84.9) | 106 (87.6) | 110 (88.0) | 114 (91.2) | |||
| MSI-H | 17 (13.6) | 17 (13.4) | 10 (8.1) | 16 (13.1) | 0.49 | 18 (14.4) | 16 (13.3) | 11 (8.9) | 15 (11.7) | 0.57 | 19 (15.1) | 15 (12.4) | 15 (12.0) | 11 (8.8) | 0.50 |
| BRAF mutation status | |||||||||||||||
| Wild type | 104 (85.2) | 107 (89.9) | 109 (90.8) | 106 (93.0) | 108 (91.5) | 103 (87.3) | 112 (95.7) | 103 (84.4) | 103 (88.8) | 110 (91.7) | 106 (89.1) | 107 (89.2) | |||
| V600E mutant | 18 (14.8) | 12 (10.1) | 11 (9.2) | 8 (7.0) | 0.25 | 10 (8.5) | 15 (12.7) | 5 (4.3) | 19 (15.6) | 0.02 | 13 (11.2) | 10 (8.3) | 13 (10.9) | 13 (10.8) | 0.88 |
BMI, body mass index; CRC, colorectal cancer; MET h/week, metabolic equivalent hours per week; MSI, microsatellite instability; MSI-H, microsatellite instability high; MSS/MSI-L, microsatellite stable/ microsatellite instability-low.
*p Values are for the significance of the analysis of variance test for continuous variables and of the χ2test for categorical variables.
†Continuous variables presented as mean±SD; categorical variables presented as number.