Observed adverse drug events (ADEs) and related drugs
| ADEs | N | Related drugs |
|---|---|---|
| Hyponatremia | 27 | Furosemide, fentanyl, carbamazepine, vigabatrin topiramate, hydrochlorothiazide, somatostatin, vancomycin, rifampicin, ranitidine, phenytoin |
| Hyperglycemia | 17 | Dexamethasone, hydrocortisone, methylprednisolone, terbutaline, tacrolimus |
| Hypokalaemia | 13 | Amphotericin B, terbutaline, furosemide, ranitidine |
| Skin rash and urticaria | 11 | Vancomycin, dipyrone, cefepime, ceftriaxone, levetiracetam, dipyrone, rasburicase |
| Hypoventilation/desaturation of oxygen | 6 | Midazolam, propofol, fentanyl, morphine, diazepam |
| Bradycardia | 4 | Midazolam |
| Hypotension | 4 | Midazolam, furosemide, thiopental, chlorpromazine |
| Liver enzyme abnormalities | 4 | Meropenem, carbamazepine, amlodipine, carvedilol, clonidine, amitriptyline, phenobarbital |
| Hypertension | 3 | Prednisone tacrolimus, dopamine |
| Increased BUN and creatine | 3 | Vancomycin, tacrolimus |
| Seizure | 2 | Hydrocortisone, liposomal amphotericin B, cefepime |
| Tachycardia | 2 | Terbutaline |
| Anemia | 2 | Ketoprofen, paracetamol |
| Extrasystole | 2 | Carvedilol, terbutaline |
| Increased number of platelets | 2 | Meropenem, ceftriaxone |
| Vomiting | 2 | Nitroprusside, tacrolimus |
| Cardiorespiratory arrest | 1 | Dipyrone |
| Thrombocytopenia | 1 | Dipyrone |
| Apnea | 1 | Phenytoin |
| Leucopoenia | 1 | Imipenem |
| Stevens-Johnson syndrome | 1 | Trimethoprim/sulfamethoxazole |
| Eosinophilia | 1 | Ceftriaxone |
BUN, blood urea nitrogen.