Measurements
| Measurements | Group |
| Clinical | |
| Demographics | All |
| Physical examination | All |
| Peripheral blood (routine measurements) | All |
| Presence of metabolic syndrome | All |
| ECG | B, D1-4 |
| BODE index | B, D1-4 |
| Fagerstrom Smoking Questionnaire | All |
| St George's Respiratory Questionnaire (SGRQ) | D1-4 |
| Clinical COPD (chronic obstructive pulmonary disease) Questionnaire (CCQ) | D1-4 |
| SQUASH | All |
| Urine (microproteins) | All |
| AGE (Advanced Glycation Endproducts)-reader | All |
| Skin blanching test | All |
| Physiological | |
| Flow volume+reversibility | All |
| Body plethysmography | All |
| CO diffusion | All |
| Methacholine challenge test | A, B, C, D1-3 |
| Bioelectrical impedance | All |
| Six minute walking distance | B, D1-4 |
| Immunological | |
| Sputum induction (only baseline) | A, B, C, D2 |
| Peripheral blood (systemic inflammation) | All |
| Peripheral blood 4× (acute smoking) | A, B, C, D2 |
| Exhaled breath condensate 3× (acute smoking) | A, B, C, D2 |
| Exhaled CO 5× (acute smoking) | A, B, C, D2 |
| Bronchial biopsy 2× (acute smoking) | A, B, C, D2 |
| Epithelial lining fluid 2× (acute smoking) | A, B, C, D2 |
| Epithelial brushes 2× (acute smoking) | A, B, C, D2 |
| Radiographical | |
| Low dose HRCT-scan lung | All |
HRCT, high resolution computed tomography.