0 | Drug error without potential harm | Not applicable |
1 | Significant | Gastrointestinal complaints |
| | Therapeutically ineffective dose according to eGFR |
| | Mild neurological effects (e.g. motoric dysfunction) |
| | Hepatic dysfunction |
| | Any significant event identified by patient which does not require change in therapy |
2 | Serious | Hypoglycaemia |
| | Nephrotoxicity or increased risk nephrolithiasis |
| | Electrolyte disturbances (e.g. hyperpotassiemia) |
| | Altered mental status due to sedation |
| | Myopathy or rhabdomyolysis |
| | Gastrointestinal bleed |
3 | Life threatening | Lactic acidosis |
| | Cardiac arrhythmia |
| | Decline in mental status with risk of falling |
| | Respiratory failure requiring intubation (e.g. bronchospasms) |
4 | Fatal | Death |