Baseline characteristics in patients with a first event of acute myocardial infarction (AMI) or unstable angina pectoris (UAP) and ORs for presenting with AMI for two periods (1996–2002 and 2003–2009)
| UAP | AMI | Age-adjusted and sex-adjusted OR | Multiple-adjusted OR (99% CI)* | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1996–2002 | 2003–2009 | 1996–2002 | 2003–2009 | 1996–2002 | p Value | 2003–2009 | p Value | 1996–2002 | p Value | 2003–2009 | p Value | |
| n | 27 210 | 20 176 | 43 193 | 54 767 | ||||||||
| Age, mean years | 68.0 | 68.5 | 69.6 | 69.7 | 1.02 (1.02 to 1.02) | <0.001 | 1.02 (1.02 to 1.02) | <0.001 | 1.03 (1.03 to 1.03) | <0.001 | 1.03 (1.03 to 1.03) | <0.001 |
| Women | 12 164 (44.7) | 8931 (44.3) | 16351 (37.9) | 20 665 (37.7) | 0.67 (0.64 to 0.70) | <0.001 | 0.68 (0.65 to 0.72) | <0.001 | 0.72 (0.69 to 0.74) | <0.001 | 0.74 (0.70 to 0.78) | <0.001 |
| Never smoking | 13 194 (55.7) | 8941 (49.2) | 20 344 (51.6) | 22 541 (45.1) | 1.00 | <0.001 | 1.00 | <0.001 | 1.00 | <0.001 | 1.00 | <0.001 |
| Former smoking | 6356 (26.8) | 6078 (33.5) | 9218 (23.4) | 14 702 (29.4) | 0.93 (0.88 to 0.98) | <0.001 | 0.94 (0.89 to 0.99) | 0.01 | 1.00 (0.97 to 1.04) | ns | 0.97 (0.92 to 1.02) | ns |
| Current smoking | 4144 (17.5) | 3137 (17.3) | 9841 (25.0) | 12 704 (25.4) | 1.82 (1.71 to 1.93) | <0.001 | 1.84 (1.72 to 1.96) | <0.001 | 1.72 (1.64 to 1.80) | <0.001 | 1.71 (1.59 to 1.82) | <0.001 |
| Hypertension | 9109 (36.6) | 9007 (46.1) | 13 425 (32.2) | 22 285 (41.0) | 0.86 (0.82 to 0.89) | <0.001 | 0.94 (0.92 to 0.96) | <0.001 | 1.05 (1.02 to 1.07) | <0.001 | 1.00 (0.97 to 1.03) | ns |
| Heart failure | 3023 (11.1) | 1685 (8.4) | 2701 (6.3) | 3105 (5.7) | 0.47 (0.43 to 0.50) | <0.001 | 0.47 (0.43 to 0.50) | <0.001 | 0.62 (0.58 to 0.67) | <0.001 | 0.74 (0.67 to 0.82) | <0.001 |
| Diabetes | 3768 (13.8) | 3307 (16.4) | 6675 (15.5) | 9599 (17.5) | 1.14 (1.07 to 1.20) | <0.001 | 1.08 (1.02 to 1.14) | 0.01 | 1.45 (1.38 to 1.52) | <0.001 | 1.43 (1.34 to 1.53) | <0.001 |
| Peripheral arterial disease | 1036 (3.8) | 698 (3.5) | 1717 (4.0) | 2080 (3.8) | 0.98 (0.88 to 1.09) | ns | 1.04 (0.93 to 1.17) | Ns | 1.32 (1.20 to 1.44) | <0.001 | 1.41 (1.23 to 1.61) | <0.001 |
| Aspirin | 11 879 (46.5) | 8832 (45.0) | 11 054 (26.2) | 14 239 (26.3) | 0.38 (0.36 to 0.40) | <0.001 | 0.39 (0.37 to 0.41) | <0.001 | 0.57 (0.54 to 0.59) | <0.001 | 0.56 (0.53 to 0.59) | <0.001 |
| β-Blockers | 10 931 (42.8) | 8640 (44.1) | 10 709 (25.4) | 15 034 (27.8) | 0.45 (0.43 to 0.47) | <0.001 | 0.47 (0.45 to 0.50) | <0.001 | 0.74 (0.71 to 0.76) | <0.001 | 0.74 (0.70 to 0.78) | <0.001 |
| ACE inhibitors | 4008 (15.7) | 3462 (17.7) | 4949 (11.7) | 7731 (14.3) | 0.69 (0.65 to 0.74) | <0.001 | 0.76 (0.71 to 0.80) | <0.001 | 1.00 (0.95 to 1.05) | ns | 1.05 (0.98 to 1.12) | ns |
| Long-acting nitrates | 8044 (31.6) | 4209 (21.5) | 4559 (10.8) | 3581 (6.6) | 0.23 (0.22 to 0.25) | <0.001 | 0.23 (0.22 to 0.24) | <0.001 | 0.33 (0.31 to 0.34) | <0.001 | 0.36 (0.33 to 0.39) | <0.001 |
| Statins | 4133 (16.3) | 5685 (29.0) | 2711 (6.4) | 7547 (14.0) | 0.37 (0.35 to 0.40) | <0.001 | 0.40 (0.38 to 0.42) | <0.001 | 0.67 (0.64 to 0.70) | <0.001 | 0.60 (0.56 to 0.64) | <0.001 |
*Adjusted for age, smoking, hypertension, heart failure, diabetes, peripheral arterial disease, aspirin, β-blockers, ACE inhibitors, long-acting nitrates and statins.