Multivariate models for rate of change in lung function (in l/year) and both Alu and LINE-1 methylation*
| Alu | LINE-1 | |||
|---|---|---|---|---|
| β | p Value | β | p Value | |
| FEV1 rate | −0.0028 | 0.49 | −0.0069 | 0.005 |
| FVC rate | −0.00098 | 0.84 | −0.0096 | 0.0021 |
| ratio rate | −0.00079 | 0.17 | 0.00005 | 0.89 |
*Adjusted for age, height, race, BMI, pack-years of smoking, smoking status and baseline FEV1, FVC or FEV1/FVC respectively depending on outcome. Models with LINE-1 also adjusted for per cent lymphocytes.
BMI, body mass index; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; LINE-1, long-interspersed nuclear elements.