Table 1

Estimated mean (LSmean±SE) average changes in urges-to-smoke scores and corresponding comparisons between treatments (estimated treatment difference (97.5% CI) and Bonferroni-adjusted p value) at 1, 3, 5 and 10 min postadministration by treatment

Average score changes from baseline (mm)*
TimeNicotine mouth spray 2 mgNicotine lozenge 2 mgNicotine lozenge 4 mgSpray vs 2 mg lozengeSpray vs 4 mg lozenge
1 min−11.91±0.72−3.97±0.72−4.80±0.72−7.9 (−9.8, −6.1) p<0.001−7.1 (−9.0, −5.2) p<0.001
3 min−23.65±1.21−10.14±1.20−11.62±1.20−13.5 (−16.4, −10.6) p<0.001−12.0 (−14.9, −9.1) p<0.001
5 min−29.19±1.32−15.27±1.31−17.03±1.31−13.9 (−16.9, −10.9) p<0.001−12.2 (−15.2, −9.2) p<0.001
10 min−35.78±1.45−23.34±1.44−25.46±1.44−12.4 (−15.5, −9.4) p<0.001−10.3 (−13.4, −7.3) p<0.001
  • *AUCn min/nbaseline urges-to-smoke score (mm).

  • AUC, area under the urges-to-smoke-vs.-time curve