Adverse drug reactions in patients not exposed to cancer chemotherapy
| ATC* | Drug | Age† | Adverse drug event | Naranjo score‡ | Avoidable? | Licensing state |
|---|---|---|---|---|---|---|
| A | Ranitidine | Newborn | Urticaria | 6 | No | Licensed |
| J | Amoxicilline | Baby/toddler | Vomiting | 6 | No | Licensed |
| J | DKTP/HIB vaccine | Baby/toddler | Dyspnoea | 5 | No | Licensed |
| J | DKTP/HIB vaccine | Baby/toddler | Fever, vomiting | 6 | No | Licensed |
| J | DKTP/HIB vaccine | Baby/toddler | Fever | 6 | No | Licensed |
| J | DKTP/HIB vaccine | Baby/toddler | Fever, refusal of food | No | ||
| Pneumococcal vaccine | 4 | Licensed | ||||
| J | DKTP/HIB vaccine | Baby/toddler | Fever | No | ||
| Pneumococcal vaccine | 4 | Licensed | ||||
| J | Tobramycin | Child | Haemorrhage | 9 | No | Unlicensed |
| J | Tobramycin | Child | Haemorrhage | 10 | No | Unlicensed |
| J | Trimethoprim | Newborn | Vomiting | 6 | Yes | Unlicensed |
| L | Infliximab | Child | Fever, tachycardia, abdominal pain | 6 | No | Licensed |
| L | Tacrolimus | Child | Vomiting | 4 | No | Licensed |
| L | Thymocytenglobuline | Child | Serum sickness | 6 | No | Unlicensed |
| N | Lithium (transmission through placenta) | Newborn | Syncope | 6 | No | Unlicensed |
| N | Valproic acid | Child | Drowsiness | 8 | Yes | Licensed |
*Anatomical Therapeutical Chemical (ATC) classification system of the WHO. A, alimentary tract and metabolism; C, cardiovascular system; J, anti-infectives for systemic use; L, antineoplastic and immunomodulating agents N, nervous system.15
†Patient age by means of EMeA criteria: preterm, newborn (0–1 month), baby/toddler (1 month–2 years), child (2–11 years) and adolescent (12–18 years).
‡Probability measured by Naranjo score: ≤0 Adverse Drug Reactions (ADR) doubtful, 1–4 ADR possible, 5–8 ADR likely, ≥9 ADR certain.11
DKTP, Difteria Pertussis Tetanus Polio vaccin; EMeA, European Medicines (Evaluation) Agency; HIB, Haemophylus Influenza B vaccin.