Events/patients (N/N) | Events/patients (N/N) | HR (95% CI) | p Value | |
Insulin only | Metformin only | Insulin only vs metformin only | ||
Any CVD | 2389/11 427 | 1734/14 317 | 1.18 (1.07 to 1.29) | <0.001 |
Fatal CVD | 681/12 285 | 264/14 696 | 1.12 (0.91 to 1.40) | 0.29 |
Any acidosis/serious infection | 1867/11 860 | 1154/14 517 | 1.28 (1.14 to 1.43) | <0.001 |
Fatal acidosis/serious infection | 325/12 284 | 127/14 697 | 1.45 (1.07 to 1.97) | 0.019 |
All-cause mortality | 2002/12 291 | 971/14 697 | 1.34 (1.19 to 1.50) | <0.001 |
Other OHA only | Metformin only | Other OHA only vs metformin only | ||
Any CVD | 929/4964 | 1734/14 317 | 1.02 (0.93 to 1.12) | 0.71 |
Fatal CVD | 237/5171 | 264/14 696 | 1.03 (0.84 to 1.26) | 0.80 |
Any acidosis/serious infection | 623/5062 | 1154/14 517 | 1.05 (0.94 to 1.18) | 0.41 |
Fatal acidosis/serious infection | 109/5171 | 127/14 697 | 1.13 (0.83 to 1.53) | 0.44 |
All-cause mortality | 745/5171 | 971/14 697 | 1.13 (1.01 to 1.27) | 0.032 |
Each comparison was adjusted by stratification with octiles of propensity scores.
CVD, cardiovascular disease; OHA, oral hypoglycaemic agent.