Table 1

Single-factor LR models based directly off male and female RP tree split criteria (see figures 1 and 2)

GenderRP splitGeneSNPGenotypesFull dataRP-subsetted data
OR (95% CI)p ValueSubsetOR (95% CI)p Value
MalePrimaryANKK1#rs1800497T/T versus C/C + C/T2.55 (1.44 to 4.51)0.001*–––
LeftGNRH1novel SNPT/T versus C/C + T/C1.43 (1.09 to 1.88)0.011M11.57 (1.18 to 2.08)0.002*
FemalePrimaryDRD2rs2242592C/C + T/C versus T/T1.32 (1.08 to 1.62)0.006*–––
Left 1APOC3rs2854116T/T versus C/C + T/C1.28 (1.04 to 1.57)0.018F11.55 (1.15 to 2.09)0.004*
Left 2ACVR2Brs3749386C/C + T/T versus T/C1.11 (0.91 to 1.36)0.302F22.17 (1.37 to 3.44)0.001*
Right 1FTOrs1421085C/C + T/T versus T/C1.32 (1.08 to 1.62)0.007*F31.65 (1.24 to 2.18)0.0005*
Right 2IL6rs1800795C/C + G/G versus C/G1.12 (0.92 to 1.37)0.269F41.85 (1.19 to 2.89)0.006*

  • Each SNP split was first run on the full data set to represent single main factor effects (‘full data’) for both men and women. Then, the same SNP splits were run on specific subsets of data per RP tree splits (M1, F1–F4; ‘RP-subsetted data’).

  • M1: LR analysis was run for only those with genotype DRD2 rs1800497 C/C or C/T.

  • F1: LR analysis was run for only those with genotype DRD2 rs2242592 T/T.

  • F2: LR analysis was run for only those with genotypes DRD2 rs2242592 T/T and APOC3 rs2854116 T/T.

  • F3: LR analysis was run for only those with genotype DRD2 rs2242592 C/C or T/C.

  • F4: LR analysis was run for only those with genotypes DRD2 rs2242592 C/C or T/C and FTO rs1421085 T/C.

  • #rs1800497 is historically known as the DRD2 Taq1A allele.

  • ↵* p<0.009

  • LR, logistic regression; RP, recursive partitioning; SNP, single nucleotide polymorphism.