ICU LOS >3 days (all patients), OR (95% CI) | ICU LOS >3 days (ICU survivors only), OR (95% CI) | HE duration >1 h, OR (95% CI) | HSI >150 mm Hg·min, OR (95% CI) | Rise in serum creatinine, OR (95% CI) | |
Fluid resuscitation | 0.71* (0.57 to 0.90) | 0.71* (0.55 to 0.91) | 0.89 (0.70 to 1.14) | 1.26* (1.01 to 1.57) | 1.14 (0.90 to 1.45) |
Use of vasoactive agents | 1.05 (0.84 to 1.30) | 1.29* (1.01 to 1.65) | 0.29* (0.23 to 0.36) | 0.72* (0.59 to 0.89) | 1.44* (1.15 to 1.80) |
Age (year) | 1.00 (0.99 to 1.00) | 0.99* (0.99 to 1.00) | 1.00 (1.00 to 1.01) | 1.01* (1.00 to 1.01) | 1.01 (1.00 to 1.01) |
Gender (male) | 0.96 (0.81 to 1.15) | 0.99 (0.81 to 1.20) | 0.83 (0.69 to 1.01) | 0.85 (0.71 to 1.01) | 1.07 (0.88 to 1.29) |
SAPS | 1.07* (1.05 to 1.09) | 1.13* (1.10 to 1.15) | 0.96* (0.94 to 0.98) | 0.99 (0.97 to 1.01) | 1.02* (1.00 to 1.04) |
Elixhauser | 1.24* (1.18 to 1.30) | 1.23* (1.17 to 1.29) | 1.19 (0.95 to 1.48) | 1.13 (1.00 to 1.27) | 2.14* (1.30 to 3.52) |
Mean MAP prior to HE (mm Hg) | 1.03* (1.02 to 1.04) | 1.04* (1.03 to 1.05) | 0.95* (0.94 to 0.96) | 0.98* (0.97 to 0.99) | 1.00 (0.99 to 1.01) |
Urine output prior to HE >200 ml | 0.73* (0.61 to 0.87) | 0.76* (0.63 to 0.92) | 1.29* (1.06 to 1.56) | 1.10 (0.92 to 1.30) | 0.75* (0.62 to 0.90) |
Creatinine prior to HE (mg/dl) | 1.01 (0.93 to 1.09) | 1.05 (0.95 to 1.15) | 0.98 (0.90 to 1.07) | 0.99 (0.92 to 1.08) | 1.01 (0.92 to 1.11) |
Service type | |||||
MICU† | 1 | 1 | 1 | 1 | 1 |
SICU | 1.61* (1.26 to 2.07) | 1.62* (1.23 to 2.13) | 0.77 (0.59 to 1.01) | 0.76* (0.60 to 0.97) | 1.00 (0.78 to 1.29) |
CCU | 1.20 (0.91 to 1.58) | 1.34 (0.99 to 1.81) | 0.70* (0.52 to 0.94) | 0.78 (0.60 to 1.02) | 1.23 (0.93 to 1.63) |
CSRU | 0.77* (0.60 to 0.98) | 0.58* (0.44 to 0.76) | 0.65* (0.50 to 0.84) | 0.58* (0.46 to 0.74) | 1.99* (1.55 to 2.56) |
Number of subjects | 2332 | 2114 | 2332 | 2332 | 1989 |
AUC | 0.692 | 0.721 | 0.733 | 0.624 | 0.635 |
Hosmer–Lemeshow p value | 0.22 | 0.42 | 0.02 | 0.16 | 0.69 |
Each column represents a separate regression model for each secondary outcome variable.
↵* Statistically significant.
↵† Reference.
AUC, area under the receiver operating characteristic curve; CCU, coronary care unit; CSRU, cardiac surgery recovery unit; HE, hypotensive episode; HSI, Hypotension Severity Index; ICU, intensive care unit; LOS, length of stay; MAP, mean arterial pressure; MICU, medical ICU; SAPS, Simplified Acute Physiology Score; SICU, surgical ICU.