Table 3

Cox univariate and multivariate analyses of overall survival

VariableOverall survival
HR (95% CI)p Value
Univariate analysis
 Age
  <50 vs ≧500.805 (0.292 to 2.217)0.675
 Stage
  III/IV vs I/II2.567 (1.404 to 4.694)0.002
 Grade
  G3 vs G2 vs G11.914 (0.981 to 3.733)0.057
 Depth of endometrial invasion
  >1/2 vs ≦1/25.539 (1.918 to 15.998)0.002
 Lymph node invasion
  Positive versus negative0.556 (0.261 to 1.183)0.127
 ER status
  Positive versus negative1.939 (0.552 to 6.807)0.301
 PR status
  Positive versus negative0.987 (0.315 to 3.035)0.970
 γ-Synuclein
  Positive versus negative27.729 (3.692 to 208.257)0.003
Multivariate analysis
 Stage
  III/IV vs I/II2.903 (1.010 to 8.340)0.048
 Depth of invasion
  >1/2 vs ≦1/22.831 (1.033 to 7.757)0.031
 γ-Synuclein
  Positive versus negative
  >1/2 vs ≦1/212.331 (1.429 to 101.892)0.020
  • Multivariable analysis was performed using stepwise Cox proportional hazards regression with forward selection. Candidate exploratory variables included clinical age, grade, stage, depth of invasion, lymph node invasion, ER status, PR status and γ-synuclein.