Incidence rate and RR of bleed events and negative controls for users of low–moderate serotonin affinity antidepressants compared with users of high-serotonin affinity antidepressants
| Outcome | Low–moderate affinity antidepressant | High-affinity antidepressant | RR (95% CI) | |||
| No. of cases | Incidence rate (per 1000 person-months) | No. of cases | Incidence rate (per 1000 person-months) | Unadjusted | Adjusted* | |
| Primary outcomes | ||||||
| Gastrointestinal haemorrhage | 333 | 7.5 | 601 | 8.0 | 1.16 (1.02 to 1.29) | 1.17 (1.02 to 1.34) |
| Stroke | ||||||
| All stroke | 434 | 9.8 | 776 | 10.4 | 1.16 (1.03 to 1.30) | 1.18 (1.06 to 1.32) |
| Ischaemic stroke | 367 | 8.3 | 672 | 9.0 | 1.17 (1.04 to 1.33) | 1.20 (1.06 to 1.35) |
| Haemorrhagic stroke | 105 | 2.4 | 176 | 2.4 | 1.10 (0.87 to 1.40) | 1.13 (0.90 to 1.44) |
| Myocardial infarction | 387 | 8.7 | 630 | 8.4 | 1.04 (0.92 to 1.18) | 1.05 (0.93 to 1.18) |
| Negative control events | ||||||
| Acute liver failure | 382 | 8.6 | 611 | 8.2 | 1.00 (0.88 to 1.13) | 1.01 (0.89 to 1.15) |
| Acute renal failure | 363 | 8.2 | 542 | 7.3 | 0.94 (0.82 to 1.07) | 0.95 (0.84 to 1.08) |
| Asthma | 909 | 20.5 | 1350 | 18.1 | 0.96 (0.88 to 1.04) | 0.94 (0.87 to 1.02) |
| Breast cancer | 333 | 7.5 | 469 | 6.3 | 0.90 (0.79 to 1.04) | 0.83 (0.73 to 0.96) |
| Hip fractures | 71 | 1.6 | 113 | 1.5 | 0.99 (0.74 to 1.33) | 0.95 (0.71 to 1.27) |
↵* Adjusted for age, sex, race, aspirin use and exposure period.