Age- and multivariable-adjusted HRs for incident vascular events according to RLS status in the PHS
| Primary analysis (n=19 182) | Sensitivity analysis* (n=15 625) | |||
| No RLS history (n=17 809) | Any history of RLS (n=1373) | No RLS history (n=14 578) | Any history of RLS (n=1047) | |
| HR (95% CI) | HR (95% CI) | |||
| Major cardiovascular event | n=974 | n=90 | n=755 | n=61 |
| Age adjusted | 1.00 | 1.09 (0.88 to 1.35) | 1.00 | 1.03 (0.79 to 1.33) |
| Multivariable adjusted† | 1.00 | 1.01 (0.81 to 1.25) | 1.00 | 0.96 (0.74 to 1.25) |
| Any stroke | n=357 | n=24 | n=271 | n=18 |
| Age adjusted | 1.00 | 0.77 (0.51 to 1.17) | 1.00 | 0.82 (0.51 to 1.33) |
| Multivariable adjusted† | 1.00 | 0.73 (0.48 to 1.11) | 1.00 | 0.79 (0.49 to 1.28) |
| Myocardial infarction | n=392 | n=39 | n=315 | n=25 |
| Age adjusted | 1.00 | 1.23 (0.88 to 1.71) | 1.00 | 1.06 (0.70 to 1.59) |
| Multivariable adjusted† | 1.00 | 1.12 (0.80 to 1.55) | 1.00 | 0.97 (0.64 to 1.45) |
| Coronary revascularisation | n=1239 | n=113 | n=976 | n=87 |
| Age adjusted | 1.00 | 1.15 (0.95 to 1.40) | 1.00 | 1.22 (0.98 to 1.52) |
| Multivariable adjusted† | 1.00 | 1.06 (0.88 to 1.29) | 1.00 | 1.12 (0.90 to 1.40) |
| CVD death | n=350 | n=39 | n=260 | n=25 |
| Age adjusted | 1.00 | 1.27 (0.91 to 1.77) | 1.00 | 1.17 (0.78 to 1.77) |
| Multivariable adjusted† | 1.00 | 1.22 (0.87 to 1.70) | 1.00 | 1.13 (0.75 to 1.70) |
↵* 3557 men with a history of polyneuropathy, kidney disease, liver disease, liver cirrhosis, rheumatoid arthritis, intermittent claudication and men who underwent peripheral artery disease surgery were excluded.
↵† Adjusted for age, randomised treatment assignments, history of hypertension, history of diabetes, history of hypercholesterolaemia, parental history of myocardial infarction, history of migraine, alcohol consumption, body mass index, smoking and exercise.
CVD, cardiovascular disease; PHS, Physician's Health Study; RLS, restless legs syndrome.