Echocardiographic characteristics at the Framingham Offspring Study visit 6 (N=2337)
| Echocardiographic measure | Adjusted for age and body mass index | Adjusted for age hypertension, body mass index, renal dysfunction, diabetes, alcohol use, smoking and total cholesterol/HDL cholesterol ratio | ||||
| Gout | No gout | p Value | Gout | No gout | p Value | |
| Mean LV thickness (cm) | 2.02 | 1.89 | <0.0001 | 1.99 | 1.89 | <0.0001 |
| Mean LV fractional shortening (range 0–1) | 0.35 | 0.37 | 0.006 | 0.35 | 0.37 | 0.005 |
| Mean LV diastolic internal dimension (cm) | 5.00 | 4.79 | <0.0001 | 4.96 | 4.79 | 0.003 |
| Mean LV mass (g) | 188.51 | 159.29 | <0.0001 | 182.47 | 159.58 | <0.001 |
| Proportion of participants with systolic dysfunction (%)* | 12.7 | 3.5 | <0.0001 | 10.0 | 2.3 | 0.002 |
| Proportion of participants with low ejection fraction (%)* | 7.7 | 2.3 | 0.001 | 5.3 | 1.6 | 0.003 |
Hypertension was defined as per JNC 7 guidelines and/or use of antihypertensive medications. Diabetes was defined using the American Diabetes Association criteria or use of anti-diabetes medications.
↵* Two-dimensional echocardiography was globally assessed by study physician for abnormal ejection fraction and evidence of mild or greater systolic dysfunction as assessed by visual assessment in multiple views.
HDL, high-density lipoprotein; LV, left ventricle.