Table 4

Haplotype analysis of DRD2 variants on current depressive symptoms (Hopkins Symptom Check List score) in the complete sample from the NFBC 1966

Gene	Variant	Haplotype	Frequency	Males and females		Males
Gene	Variant	Haplotype	Frequency	β	p Value	β	p Value
DRD2	2-SNP haplotype analysis
	rs4648318–rs4274224	GG	0.05	0.0409	0.0007	0.0694	0.00005
	rs4274224–rs4581480	GG	0.07	0.0220	0.0069	0.0321	0.0023
		AA	0.48	0.0116	0.0161	−0.0237	0.0004
	rs4581480–rs7131056	GA	0.07	0.0220	0.0071	0.0322	0.0026
	3-SNP haplotype analysis
	rs4648318–rs4274224–rs4581480	GGG	0.05	0.0326	0.0027	0.0437	0.0019
	rs4274224–rs4581480–rs7131056	GGA	0.07	0.0215	0.0081	0.0317	0.0033

Empirical p values based on permutation are reported, with p values <0.05 shown in bold.