Characteristics of participants in the general population study stratified by gender, diabetes group and filaggrin mutation status
| All (n=3335) | Women (n=1844) | Men (n=1491) | Non-diabetes group (n=3136) | Screen-detected diabetes group (n=66) | Self-reported diabetes group (n=133) | Filaggrin wild type (n=3066) | Filaggrin null mutation (n=269) | |
| Mean (±2SD) | ||||||||
| Mean age (years) | 47.5 (26.0) | 46.8 (26.2) | 48.4 (25.8) | 47.0 (26.0) | 56.1 (21.6) | 55.3 (20.4) | 47.5 (26.1) | 47.2 (25.8) |
| Weight (kg) | 76.7 (32.6) | 69.9 (28.8) | 85.1 (29.0) | 76.17 (32.0) | 83.3 (34.0) | 86.0 (39.5) | 76.7 (32.6) | 76.8 (34.4) |
| Height (m) | 1.71 (0.19) | 1.65 (0.12) | 1.79 (0.13) | 1.71 (18.4) | 1.70 (17.2) | 1.71 (19.1) | 1.71 (18.4) | 1.71 (18.6) |
| Waist (m) | 0.88 (0.58) | 0.83 (0.25) | 0.95 (0.24) | 87.9 (26.6) | 97.4 (28.0) | 100.4 (31.2) | 88.5 (27.2) | 89.4 (29.6) |
| BMI (kg/m2) | 25.9 (9.3) | 25.4 (10.0) | 26.6 (8.2) | 25.7 (9.06) | 28.7 (11.2) | 29.3 (11.6) | 25.90 (9.20) | 26.14 (10.4) |
| Systolic blood pressure (mm Hg) | 130 (35) | 127 (36) | 134 (34) | 129 (35) | 141 (39) | 137 (38) | 130 (35) | 130 (35) |
| Diastolic blood pressure (mm Hg) | 81 (21) | 79 (20) | 84 (21) | 82 (21) | 86 (23) | 82 (18) | 81 (21) | 82 (21) |
| Fasting blood glucose (mmol/l) | 5.23 (1.86) | 5.13 (1.64) | 5.36 (2.08) | 5.10 (1.20) | 7.37 (1.96) | 7.24 (5.08) | 5.22 (1.86) | 5.25 (1.68) |
| Glycated haemoglobin (%) | 5.41 (1.12) | 5.38 (0.55) | 5.45 (1.16) | 5.35 (0.92) | 6.17 (1.60) | 6.49 (2.14) | 5.41 (1.14) | 5.44 (0.90) |
| Fasting blood cholesterol (mmol/l) | 5.08 (2.04) | 5.16 (2.06) | 4.99 (1.00) | 5.10 (2.00) | 5.38 (2.50) | 4.46 (1.86) | 5.08 (2.04) | 5.06 (1.96) |
| Fasting blood high-density lipoprotein cholesterol (mmol/l) | 1.53 (0.86) | 1.68 (0.85) | 1.36 (0.72) | 1.54 (0.86) | 1.37 (0.73) | 1.37 (0.81) | 1.53 (0.85) | 1.54 (0.86) |
| Fasting blood low-density lipoprotein cholesterol (mmol/l) | 3.19 (1.94) | 3.15 (1.90) | 3.24 (1.99) | 3.21 (1.92) | 3.33 (2.57) | 2.64 (1.74) | 3.19 (1.94) | 3.17 (1.98) |
| Fasting blood triglyceride (mmol/l) | 1.29 (1.98) | 1.16 (1.24) | 1.46 (2.58) | 1.27 (1.96) | 1.76 (2.4) | 1.51 (1.42) | 1.30 (2.02) | 1.24 (1.36) |
| Fasting blood insulin (pmol/l) | 44.69 (75.61) | 41.85 (63.22) | 48.20 (88.24) | 42.50 (65.04) | 78.09 (99.66) | 79.84 (177.50) | 44.55 (76.34) | 46.21 (67.38) |
| Homeostasis model assessment of insulin resistance* | 10.84 (25.2) | 9.91 (19.1) | 12.00 (31.2) | 9.8 (16.2) | 26.3 (26.4) | 27.9 (86.2) | 10.81 (25.80) | 11.16 (19.00) |
| Percentage (n/ntotal) | ||||||||
| Filaggrin null mutation | 8.1 (269/3335) | 8.5 (157/1844) | 7.5 (112/1491) | 7.8 (246/3136) | 9.1 (6/66) | 12.8 (17/133) | – | – |
| Atopic dermatitis† | 10.0 (334/3335) | 13.1 (242/1844) | 6.2 (92/1491) | 9.9 (310/3136) | 9.1 (6/66) | 13.5 (18/133) | 9.1 (277/3066) | 21.2 (57/269) |
| Self-reported diabetes‡ | 4.0 (123/3307) | 3.3 (61/1830) | 4.9 (72/1477) | – | – | – | 3.8 (116/3042) | 6.4 (17/265) |
The study was a cross-sectional study performed in the general population in Copenhagen during 2006–2008.
* (Fasting plasma glucose (mmol/l)·fasting serum insulin (mU/l))/22.5.
† Atopic dermatitis was defined by the UK Working Party’s diagnostic criteria for atopic dermatitis as a history of an itchy skin condition plus a minimum of two of four minor criteria.18
‡ An affirmative answer to the question: ‘Have you ever been told that you suffered from diabetes?’
–, not done.