Table 2

Genes identified as up- or down-regulated in multiple sclerosis in at least three studies

GeneDescriptionDirection of change in expression in multiple sclerosis
ATP7AATPase, Cu2+ transporting, alpha polypeptideDecreased (FIN11 15 16)
CCL3Chemokine (C-C motif) ligand 3Decreased11–13
CDKN1CCyclin-dependent kinase inhibitor 1C (p57, Kip2)Decreased (FIN9 11)
HSPA1AHeat shock 70 kDa protein 1ADecreased9 12 13 15 16
PLAURPlasminogen activator, urokinase receptorDecreased11–13
EIF4A1Eukaryotic translation initiation factor 4A1Increased (FIN9 11)
NEAT1Nuclear paraspeckle assembly transcript 1 (non-protein coding)Increased (FIN9 11)
OGTO-linked N-acetylglucosamine (GlcNAc) transferaseIncreased (FIN11 12)
PTGS2Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclo-oxygenase)Increased11–13
RBBP6Retinoblastoma-binding protein 6Increased (FIN9 11)
TNFAIP3Tumour necrosis factor, alpha-induced protein 3Increased (FIN11 15 16)
ZMYND8Zinc finger, MYND-type containing 8Increased (FIN11 12)
  • FIN, previously unpublished Finnish microarray screen described in detail here.