Table 3

Meta-analysis of self-reported health symptoms in Gulf War-deployed control compared with Gulf War-era control groups

Full unadjusted meta-analysis resultsI2
SymptomNo of studies in analysisOR (95% CI)
Neurological
 Tremors and/or shaking in body parts42.68 (2.53 to 2.84)0.32
 Dizziness102.34 (2.06 to 2.67)0.42
 Recurrent headache42.34 (1.74 to 3.15)0.94
 Numbness and tingling in body parts82.32 (1.96 to 2.74)0.89
 Loss of balance/coordination32.18 (1.83 to 2.59)* 0
 Headaches181.78 (1.49 to 2.12)0.94
Mood cognition
 Feeling detached33.59 (1.83 to 7.03)* 0.81
 Irritability143.21 (2.28 to 4.52)0.96
 Nightmares52.92 (1.98 to 4.30)0.92
 Feeling anxious/anxiety82.68 (2.10 to 3.43)0.91
 Memory problems72.63 (2.10 to 3.30)0.91
 Trouble finding words72.62 (1.92 to 3.57)0.90
 Forgetful62.52 (1.80 to 3.52)0.94
 Difficulty concentrating112.47 (2.06 to 2.96)0.89
 Feeling depressed142.26 (1.88 to 2.71)0.90
Sleep, fatigue
 Fatigue152.74 (2.11 to 3.57)0.97
 Sleepiness52.49 (1.79 to 3.48)0.91
 Difficulty sleeping, falling or staying asleep111.91 (1.67 to 2.19)0.90
 Unrefreshing sleep121.91 (1.59 to 2.30)0.87
 Lacking energy31.73 (1.52 to 1.97)* 0.37
Musculoskeletal
 Muscle weakness/loss of strength53.19 (2.73 to 3.74)0.64
 Joint pain172.36 (1.99 to 2.80)0.91
 Muscle aches/pain132.36 (1.91 to 2.92)0.94
 Joint swelling32.35 (1.67 to 3.30)* 0.92
 Joint stiffness102.28 (1.79 to 2.90)0.95
 Back pain91.47 (1.27 to 1.70)0.89
Gastrointestinal
 Diarrhoea/loose stools153.24 (2.51 to 4.17)0.93
 Loss of appetite52.58 (1.90 to 3.51)0.88
 Constipation62.20 (1.77 to 2.74)0.83
 Nausea62.20 (1.61 to 3.02)0.85
 Abdominal pain and cramps112.08 (1.79 to 2.42)0.68
 Vomiting51.60 (1.45 to 1.76)* 0
 Flatulence or burping41.45 (1.15 to 1.84)* 0.88
Dermatological
 Rash143.18 (2.47 to 4.09)0.94
 Hair loss92.60 (1.85 to 3.67)0.92
 Itching31.90 (1.59 to 2.27)* 0.28
 Sweating31.67 (1.34 to 2.07)* 0.87
Cardiac
 Chest pain72.24 (1.92 to 2.61)0.75
 Rapid/racing heart beat32.04 (1.97 to 2.11)0
 Irregular heart beat31.78 (1.70 to 1.87)0.50
Genitourinary
 Pain during intercourse32.39 (2.12 to 2.70)* 0.51
 Loss of interest in sex52.34 (1.80 to 3.05)0.84
Pulmonary
 Shortness of breath62.81 (2.35 to 3.35)0.78
 Coughing112.02 (1.72 to 2.38)0.88
 Wheezing51.92 (1.66 to 2.22)0.71
 Sinus congestion91.63 (1.46 to 1.81)0.75
 Asthma71.38 (1.20 to 1.58)* 0.47
Miscellaneous
 Night sweats53.42 (2.73 to 4.29)0.72
 Bleeding gums42.99 (1.73 to 5.17)* 0.94
 Fever62.30 (1.75 to 3.03)0.77
 Lump in throat32.26 (1.62 to 3.17)* 0.65
 Weight gain32.16 (1.93 to 2.41)* 0
 Swollen glands41.98 (1.68 to 2.34)* 0.70
 Chemical sensitivity41.95 (1.60 to 2.38)0.72
 Sore throat101.82 (1.56 to 2.12)0.89
 Ringing in ears61.69 (1.42 to 2.01)0.78
  • *OR no longer significant in bias analysis; 95% CI contains null using minimum SE.