Frequency of health outcomes in the STRONG TF cohort relative to matched comparison groups
| Health outcomes | TF cohort, n (%)* | Reference males, n (%)* | Reference females, n (%)* |
| Cardiovascular disease | |||
| Venous thromboembolism | 86 (2.5) | 670 (1.9) | 677 (2.0) |
| Stroke | 88 (2.5) | 943 (2.7) | 674 (2.0) |
| Myocardial infarction | 61 (1.8) | 664 (1.9) | 319 (0.9) |
| Peripheral artery disease | 106 (3.1) | 879 (2.6) | 645 (1.9) |
| Unstable angina | 64 (1.8) | 656 (1.9) | 336 (1.0) |
| Mental health† | |||
| Anxiety | 1337 (38) | 4323 (13) | 7485 (22) |
| Depression | 1705 (49) | 4721 (14) | 8726 (25) |
| Self-inflicted injury‡ | 75 (2.2) | 100 (0.3) | 204 (0.6) |
| Suicidal ideation | 175 (5.0) | 157 (0.5) | 194 (0.6) |
| Substance abuse disorder | 524 (15) | 2860 (8.3) | 1680 (4.9) |
| Cancer primary site | |||
| Colorectum | 10 (0.3) | 107 (0.3) | 91 (0.3) |
| Lung and bronchus | 9 (0.3) | 58 (0.2) | 59 (0.2) |
| Lymphatic and haematopoietic | 22 (0.6) | 168 (0.5) | 106 (0.3) |
| Melanoma | 10 (0.3) | 227 (0.7) | 180 (0.5) |
| Prostate | 25 (0.7) | 451 (1.3) | 0 (0.0) |
| Other chronic conditions† | |||
| HIV§ | 186 (5.4) | 190 (0.6) | 15 (0.0) |
| Diabetes | 313 (9.0) | 3358 (9.8) | 2619 (7.6) |
| Vital status | |||
| Alive | 3372 (97) | 33 562 (98) | 33 839 (98) |
| Dead | 103 (3.0) | 818 (2.4) | 551 (1.6) |
| Total | 3475 (100) | 34 380 (100) | 34 390 (100) |
*Percentages do not add to 100% due to overlapping categories.
†Based on at least two diagnoses in the EMR.
‡Combined diagnoses of self-inflicted injury, self-inflicted injury/poisoning and possible self-inflicted injury.
§HIV status ascertained from disease registries in Kaiser Permanente health plans located in Northern and Southern California and from two or more International Classification of Diseases codes in the EMR in Kaiser Permanente health plan located in Georgia.
EMR, electronic medical record; STRONG, Study of Transition, Outcomes and Gender; TF, transfeminine.