ICERs: metformin
		Metformin: ICER in 2015 GBP Health system perspective			Metformin: ICER in 2015 GBP Societal perspective
Reference	Duration of analysis	Range (base case)	Mean	Unit	Range (base case)	Mean	Unit
49	Lifetime	29 409	29 409	£/QALY
48	30 years	32 430	32 430	£/QALY	33 392	33 392	£/QALY
40	10 years	Cost saving	Cost saving	£/QALY	Cost saving	Cost saving	£/QALY
57	Lifetime	5477	5477	£/QALY
58	3 years	15 371	15 371	£/QALY	4648	4648	£/QALY
54	50 years	8428	8428	£/QALY
28	Lifetime	332	332	£/QALY
61	10 years	15 339	15 339	£/QALY	Cost saving (−10 735)	Cost saving (−10 735)	£/QALY
47	Lifetime simulation	7290	7290	£/LYG
46	10 years	Cost saving (−5495)	Cost saving (−5495)	£/LYG
55	Age 100 or death	14 960	14 960	£/DALY
60	3 years	16 296	16 296	Cost per case of T2DM avoided	27 281	27 281	Cost per case of T2DM avoided

DALY, disability-adjusted life-years; DPP, Diabetes Prevention Program; GBP, British pounds; LYG, life-years gained; QALY, quality-adjusted life-years; T2DM, Type 2 Diabetes Mellitus.