Table 1

Number of patients and deaths, inhospital mortalities and HRs for total death of CVD and its subtypes according to hs-CRP levels

Diagnosis at the emergency department	Total	hs-CRP levels (mg/L)					p for trend (across categories)	Continuous log scale	p for trend (continous)
Diagnosis at the emergency department	Total	<3.0	3.1–5.4	5.5–11.5	11.6–33.2	≥33.3	p for trend (across categories)	Continuous log scale	p for trend (continous)
CVD
No of patients	12 211	7375	1212	1200	1216	1208
No of deaths	1156	517	116	134	149	240
Inhospital mortality (%)	9.5	7.0	9.6	11.2	12.3	19.9	<0.001
Age-adjusted and sex-adjusted HR (95% CI)		1 (ref.)	1.18 (0.97 to 1.45)	1.32*(1.09 to 1.60)	1.38*(1.14 to 1.65)	2.15*(1.84 to 2.51)	<0.001	1.15*(1.12 to 1.19)	<0.001
Age-adjusted, sex-adjusted and WCC-adjusted HR (95% CI)		1 (ref.)	1.15 (0.94 to 1.41)	1.29 (1.07 to 1.56)	1.33* (1.11 to 1.60)	2.00* (1.71 to 2.34)	<0.001	1.14* (1.10 to 1.18)	<0.001
Acute myocardial infarction
No of patients	1347	796	145	126	125	155
No of deaths	89	28	4	12	9	36
Inhospital mortality (%)	6.6	3.5	2.8	9.5	7.2	23.2	<0.001
Age-adjusted and sex-adjusted HR (95% CI)		1 (ref.)	0.65 (0.23 to 1.86)	1.80 (0.91 to 3.57)	1.46 (0.68 to 3.13)	4.33*(2.60 to 7.22)	<0.001	1.37*(1.23 to 1.54)	<0.001
Age-adjusted, sex-adjusted and WCC-adjusted HR (95% CI)		1 (ref.)	0.62 (0.22 to 1.76)	1.64 (0.83 to 3.26)	1.14 (0.51 to 2.54)	3.44* (2.04 to 5.82)	<0.001	1.31* (1.16 to 1.47)	<0.001
Heart failure
No of patients	1742	620	232	249	310	331
No of deaths	148	19	11	28	29	61
Inhospital mortality (%)	8.5	3.1	4.7	11.2	9.4	18.4	<0.001
Age-adjusted and sex-adjusted HR (95% CI)		1 (ref.)	1.27 (0.60 to 2.66)	2.29*(1.26 to 4.17)	1.99*(1.11 to 3.57)	3.55*(2.11 to 5.97)	<0.001	1.35*(1.22 to 1.51)	<0.001
Age-adjusted, sex-adjusted and WCC-adjusted HR (95% CI)		1 (ref.)	1.26 (0.60 to 2.64)	2.34* (1.28 to 4.26)	2.07* (1.15 to 3.72)	3.83* (2.26 to 6.49)	<0.001	1.39* (1.24 to 1.55)	<0.001
Cerebral infarction
No of patients	2879	1823	277	281	271	227
No of deaths	261	109	25	34	43	50
Inhospital mortality (%)	9.1	6.0	9.0	12.1	15.9	22.0	<0.001
Age-adjusted and sex-adjusted HR (95% CI)		1 (ref.)	1.15 (0.74to 1.78)	1.73*(1.18 to 2.55)	2.04*(1.43 to 2.91)	3.02*(2.15 to 4.22)	<0.001	1.28*(1.19 to 1.37)	<0.001
Age-adjusted, sex-adjusted and WCC-adjusted HR (95% CI)		1 (ref.)	1.07 (0.69 to 1.66)	1.59 (1.08 to 2.34)	1.63 (1.12 to 2.36)	2.20* (1.53 to 3.17)	<0.001	1.20* (1.11 to 1.29)	<0.001
Intracerebral haemorrhage
No of patients	1989	1428	167	153	137	104
No of deaths	338	201	39	32	29	37
Inhospital mortality (%)	17.0	14.1	23.4	20.9	21.2	35.6	<0.001
Age-adjusted and sex-adjusted HR (95% CI)		1 (ref.)	1.60 (1.14 to 2.26)	1.34 (0.92 to 1.95)	1.33 (0.90 to 1.97)	2.33*(1.64 to 3.32)	<0.001	1.14*(1.07 to 1.21)	<0.001
Age-adjusted, sex-adjusted and WCC-adjusted HR (95% CI)		1 (ref.)	1.56 (1.10 to 2.20)	1.32 (0.91 to 1.92)	1.29 (0.87 to 1.92)	2.05* (1.42 to 2.97)	<0.001	1.12* (1.05 to 1.19)	<0.001
Others
No of patients	4254	2708	391	391	373	391
No of deaths	320	160	37	28	39	56
Inhospital mortality (%)	7.5	5.9	9.5	7.2	10.5	14.3	0.002
Age-adjusted and sex-adjusted HR (95% CI)		1 (ref.)	1.41 (0.98 to 2.01)	0.95 (0.63 to 1.42)	1.28 (0.89 to 1.82)	1.43 (1.05 to 1.95)	0.032	1.08 (1.02 to 1.14)	0.009
Age-adjusted, sex-adjusted and WCC-adjusted HR (95% CI)		1 (ref.)	1.30 (0.91 to 1.86)	0.74 (0.48 to 1.14)	1.16 (0.85 to 1.61)	1.03 (1.02 to 1.04)	0.381	1.04 (0.98 to 1.10)	0.223

Cardiovascular disease: International Statistical Classification of Diseases and related problems 10th revision (below ICD-10) Diseases of the circulatory system (I00–I99);
acute myocardial infarction: ICD-10 (I21–I24); heart failure: ICD-10 (I50); cerebral infarction: ICD-10 (I63); intracerebral haemorrhage: ICD-10 (I61).
*Statistically significant after applying a Bonferroni correction.
CVD, cardiovascular disease; hs-CRP, high-sensitivity C reactive protein; WCC, white cell count.