Factors related to presence of aTRH
| Univariate analysis | Age and sex adjusted analysis | Multivariable-adjusted analysis | ||||
| OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| Sex (female) | 1.33 | 1.11 to 1.61 | 1.34 | 1.11 to 1.62 | 1.53 | 1.18 to 1.99 |
| Age (years) | 1.03 | 1.02 to 1.04 | 1.03 | 1.02 to 1.04 | 1.01 | 0.99 to 1.02 |
| Diabetes mellitus | 2.42 | 2.00 to 2.92 | 2.31 | 1.92 to 2.80 | 1.66 | 1.28 to 2.16 |
| History of cardiac vascular disease | 1.26 | 1.04 to 1.52 | 1.34 | 1.10 to 1.62 | 0.98 | 0.54 to 1.78 |
| History of cerebral vascular disease | 1.18 | 0.98 to 1.43 | 1.13 | 0.93 to 1.37 | 0.97 | 0.53 to 1.77 |
| History of peripheral vascular disease | 1.13 | 0.90 to 1.40 | 1.08 | 0.86 to 1.35 | 0.77 | 0.42 to 1.41 |
| History of abdominal aneurysmatic disease | 1.60 | 1.23 to 2.09 | 1.44 | 1.10 to 1.89 | 1.09 | 0.59 to 2.01 |
| Multiple locations of vascular disease | 2.12 | 1.74 to 2.59 | 1.99 | 1.63 to 2.44 | 1.53 | 0.77 to 3.01 |
| Duration of vascular disease (years) | 1.03 | 1.02 to 1.04 | 1.03 | 1.02 to 1.04 | 1.01 | 1.00 to 1.02 |
| Body mass index (kg/m²) | 1.08 | 1.06 to 1.10 | 1.09 | 1.07 to 1.12 | 1.04 | 1.00 to 1.08 |
| Waist circumference (cm) | 1.03 | 1.02 to 1.03 | 1.03 | 1.03 to 1.04 | 1.01 | 1.00 to 1.03 |
| Total cholesterol (mmol/L) | 0.92 | 0.86 to 0.99 | 0.91 | 0.84 to 0.98 | 0.95 | 0.87 to 1.04 |
| LDL cholesterol (mmol/L) | 0.83 | 0.76 to 0.91 | 0.83 | 0.76 to 0.91 | 0.88 | 0.79 to 0.97 |
| HDL cholesterol (mmol/L) | 0.83 | 0.65 to 1.06 | 0.64 | 0.49 to 0.84 | 1.04 | 0.77 to 1.40 |
| Triglycerides (mmol/L) | 1.09 | 1.04 to 1.15 | 1.13 | 1.07 to 1.19 | 1.07 | 1.02 to 1.13 |
| Fasting glucose (mmol/L) | 1.15 | 1.10 to 1.19 | 1.15 | 1.10 to 1.19 | 1.02 | 0.96 to 1.08 |
| hsCRP (mg/L) | 1.00 | 0.99 to 1.01 | 1.00 | 0.99 to 1.01 | 0.99 | 0.98 to 1.00 |
| eGFR (mL/min/1.73m²) | 0.97 | 0.97 to 0.98 | 0.97 | 0.97 to 0.98 | 0.98 | 0.97 to 0.98 |
| Albuminuria (no) | Ref | Ref | Ref | |||
| Microalbuminuria | 1.97 | 1.59 to 2.45 | 1.78 | 1.43 to 2.22 | 1.27 | 0.99 to 1.63 |
| Macroalbuminuria | 1.91 | 1.18 to 3.10 | 1.75 | 1.07 to 2.85 | 1.03 | 0.59 to 1.81 |
| Pack-years | 1.00 | 1.00 to 1.01 | 1.00 | 1.00 to 1.01 | 1.00 | 1.00 to 1.01 |
| Alcohol use (any) | 0.76 | 0.61 to 0.94 | 0.85 | 0.68 to 1.06 | 0.99 | 0.78 to 1.27 |
| Physical exercise score (METs*hours/week) | 1.00 | 1.00 to 1.00 | 1.00 | 1.00 to 1.00 | 1.00 | 1.00 to 1.00 |
| Carotid intima-media thickness (mm) | 1.84 | 1.41 to 2.40 | 1.49 | 1.11 to 2.00 | 1.20 | 0.85 to 1.68 |
| Ankle-brachialis index | 0.42 | 0.28 to 0.65 | 0.54 | 0.35 to 0.84 | 0.54 | 0.31 to 0.96 |
In the second model, age was adjusted only for sex, sex was adjusted only for age.
In the multivariate analysis, total cholesterol was used for the other factors. HDL, LDL cholesterol and triglycerides were entered separately.
aTRH, apparent therapy-resistant hypertension; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MET, metabolic equivalent.