Study period | ||||||||
Enrolment | Preintervention | Nutrition intervention | Postintervention assessment | Eligibility assessment for UGI endoscopy | UGI endoscopy and biopsy | |||
Timepoint | −T1 | 0 | Month 1 ( T1 ) | Month 2 ( T2 ) | Month 3 ( T3 ) | Week 1 ( T4 ) | Week 2 ( T5 ) | Week 3 ( T6 ) |
Enrolment | X | |||||||
Pre-enrolment survey | X | |||||||
Eligibility screen | X | |||||||
Informed consent | X | X | ||||||
Interventions | ||||||||
Stunted children | ||||||||
Children at risk of stunting | ||||||||
Malnourished adult | ||||||||
Assessments | ||||||||
SES, WASH, FFQ | X | X | ||||||
Anthropometry* | X | X | X | X | X | |||
Blood biomarkers | X | X | ||||||
Stool biomarkers and TAC | X | X | ||||||
Microbiota | X | X | ||||||
Urine L:R | X | X | ||||||
Breath SIBO | X | X | ||||||
UGI endoscopy and biopsy | X | X | ||||||
Histopathology, IHC, morphometry | X |
*Anthropometry done fortnightly.
IHC, immunohistochemistry; L:R, lactulose/rhamnose; SIBO, small intestinal bacterial overgrowth; TAC, TaqMan Array Card; UGI, upper gastrointestinal; SES, socio-economic status; WASH, water-sanitation-hygiene; FFQ, food frequency questionnaire.