Univariate analysis | Multivariate analysis* | |||
Variable | HR (95% CI) | p Value | HR (95% CI) | p Value |
Primary Sjogren’s syndrome | 1.71 (1.20 to 2.43) | 0.003 | 1.48 (1.03 to 2.12) | 0.034 |
Sex (male) | 1.78 (1.21 to 2.63) | 0.004 | 1.42 (0.96 to 2.12) | 0.083 |
Age groups, years (reference: age≤50) | ||||
51–65 | 1.93 (1.20 to 3.12) | 0.007 | 1.61 (0.99 to 2.12) | 0.055 |
>65 | 4.01 (2.54 to 6.31) | <0.001 | 2.90 (1.81 to 4.67) | <0.001 |
Baseline comorbidity | ||||
Diabetes mellitus | 3.30 (2.30 to 4.73) | <0.001 | 2.39 (1.65 to 3.46) | <0.001 |
Gallstone | 7.78 (4.56 to 13.27) | <0.001 | 5.49 (3.19 to 9.46) | <0.001 |
Hepatitis B | 2.27 (0.93 to 5.53) | 0.072 | 1.84 (0.74 to 4.54) | 0.189 |
Hepatitis C | 3.39 (1.59 to 7.25) | 0.002 | 2.06 (0.95 to 4.51) | 0.069 |
Hyperlipidaemia | 1.83 (1.22 to 2.75) | 0.004 | – | |
Hypertriglyceridaemia | 1.34 (0.19 to 9.56) | 0.085 | – | |
No of comorbidities | ||||
0 | 1 | |||
1 | 2.51 (1.72 to 3.68) | |||
≥2 | 4.97 (3.24 to 7.65) |
*All variables, except number of comorbidities, were selected using stepwise Cox regression analysis with entry and retention criteria at p≤0.2 in multivariate analysis.