Table 1

Search strategy for the MEDLINE electronic database using the Ovid interface

Database	Search Terms
MEDLINE 1946 - present	1. optic nerve/
	2. optic nerve*.ti,ab,kf.
	3. nervus opticus.ti,ab,kf.
	4. second cranial nerve*.ti,ab,kf.
	5. cranial nerve ii.ti,ab,kf.
	6. cranial nerve 2.ti,ab,kf.
	7. or/1–6
	8. oligodendroglia/ or myelin sheath/
	9. sheath.ti,ab,kf.
	10. oligodendroglia.ti,ab,kf.
	11. oligodendrocyte*.ti,ab,kf.
	12. myelin.ti,ab,kf.
	13. or/8–12
	14. diameter*.ti/ab/kf.
	15. diametre*.ti,ab,kf.
	16. dilat*.ti/ab/kf.
	17. thick*.ti,ab,kf.
	18. volume.ti,ab,kf.
	19. (swelling or swollen).ti,ab,kf.
	20. oedema.ti,ab,kf.
	21. or/14–20
	22. intracranial pressure/
	23. ((intracranial or subarachnoid*) adj2 pressure).ti,ab,kf.
	24. intracranial hypertension/
	25. intracranial hypertension.ti,ab,kf.
	26. icp.ti,ab,kf.
	27. papilledema/
	28. papilledema*.ti,ab,kf.
	29. or/22–28
	30. (7 or 13) and 21 and 29